Plausible involvement of a diabetic serum factor in neutrophil membrane pathology.

N. Nath, S. Biswas, A. Bhelwa, A. Ittoop, S. Biswal

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


With a view to determining the role of diabetic serum factor (DSF) in the progression of membrane pathology, time-dependent preincubation effects of DSF on certain membrane-bound enzymes of normal polymorphonuclear leucocytes (PMNL) have been studied. DSF is found to cause significant decrements in the activities of Na+/K+ ATPase, PLC and AcE of PMNL on in vitro incubation for 60 min, while the effect on Ca2+/Mg2+ ATPase appears only on prolonged incubation with an initial hike in activity at 5 min. The implications of these results have been discussed.

Original languageEnglish (US)
Pages (from-to)244-246
Number of pages3
JournalIndian journal of biochemistry & biophysics
Issue number4
StatePublished - Aug 1993
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry


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