Platelet Pathophysiology and its Role in Thrombosis

Paul A. Gurbel, Udaya S. Tantry

Research output: Chapter in Book/Report/Conference proceedingChapter


Multiple lines of evidence support the important role of platelets in thrombosis and subsequent clinical manifestations. Following platelet activation, the two agonists such as thromboxane A2 (TxA2) and adenosine diphosphate (ADP) generated at the site of vascular injury play a critical role in the amplification of platelet activation in response to other stimuli and in the final activation of glycoprotein (GP) IIb/IIIa receptors. Currently, the antiplatelet agents such as aspirin (inhibits platelet cyclooxygenase-1 enzyme and subsequent TxA2 generation), P2Y12 receptor blockers, and GPIIb/IIIa blockers constitute a major part of the pharmacological strategy to prevent thrombosis, an important cause of myocardial infarction and death.

Original languageEnglish (US)
Title of host publicationAntiplatelet Therapy in Cardiovascular Disease
Number of pages7
ISBN (Electronic)9781118493984
ISBN (Print)9781118275757
StatePublished - Jun 3 2014


  • Coagulation
  • Coronary artery disease
  • Cyclooxygenase-1 enzyme
  • GPIIb/IIIa receptor
  • Hemostasis
  • Myocardial infarction
  • P2Y12 receptor
  • Platelets
  • Stent thrombosis
  • Thrombosis

ASJC Scopus subject areas

  • Medicine(all)


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