Platelet function in patients with depression

Kapil Parakh, Ankit Sakhuja, Utsav Bhat, Roy C. Ziegelstein

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Depression accelerates the development and progression of cardiovascular disease and confers an increased risk of mortality. Platelets share biochemical similarity with the central nervous system, particularly in the uptake, storage, and metabolism of serotonin. Given this similarity, and considering the central role of platelets in the biology of cardiovascular disease, it is highly plausible that platelets play an important role in the increased cardiovascular risk of patients with depression. This article provides a comprehensive review of the evidence in this area and shows that the relationship between depression and platelet function is hardly straightforward. Whereas many studies have found that patients with depression have exaggerated platelet activation, quite a number of others show no such relationship or even lower levels of platelet activation in patients with depression. Larger, carefully designed, adequately powered studies with standardized methods of assessing platelet function are needed to address this issue.

Original languageEnglish (US)
Pages (from-to)612-617
Number of pages6
JournalSouthern medical journal
Issue number6
StatePublished - Jun 2008
Externally publishedYes


  • Cardiovascular diseases
  • Depression
  • Platelets
  • Selective serotonin reuptake inhibitor
  • Serotonin

ASJC Scopus subject areas

  • Medicine(all)


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