TY - JOUR
T1 - Platelet-Derived Growth Factor is Chemotactic for Human Retinal Pigment Epithelial Cells
AU - Campochiaro, Peter A.
AU - Glaser, Bert M.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1985/4
Y1 - 1985/4
N2 - The presence of blood or serum in the vitreous cavity has been associated with the formation of cellular membranes in proliferative vitreoretinopathy and after penetrating ocular trauma. Retinal pigment epithelial (RPE) cells are an important component of these membranes. For RPE cells to effectively spread throughout the vitreous cavity and form contractile membranes, cell migration must occur. Serum has been shown to initiate RPE cell migration. Fibronectin (FN), a glycoprotein found in serum, stimulates RPE cell migration but accounts for only part of the stimulatory effect of serum. We report that another serum component, platelet-derived growth factor (PDGF), also stimulates RPE cell migration. Furthermore, the effect of PDGF and FN are additive and together probably account for a large part of the chemotactic activity found in serum.
AB - The presence of blood or serum in the vitreous cavity has been associated with the formation of cellular membranes in proliferative vitreoretinopathy and after penetrating ocular trauma. Retinal pigment epithelial (RPE) cells are an important component of these membranes. For RPE cells to effectively spread throughout the vitreous cavity and form contractile membranes, cell migration must occur. Serum has been shown to initiate RPE cell migration. Fibronectin (FN), a glycoprotein found in serum, stimulates RPE cell migration but accounts for only part of the stimulatory effect of serum. We report that another serum component, platelet-derived growth factor (PDGF), also stimulates RPE cell migration. Furthermore, the effect of PDGF and FN are additive and together probably account for a large part of the chemotactic activity found in serum.
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U2 - 10.1001/archopht.1985.01050040118034
DO - 10.1001/archopht.1985.01050040118034
M3 - Article
C2 - 3985844
AN - SCOPUS:0021957738
SN - 0003-9950
VL - 103
SP - 576
EP - 579
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 4
ER -