Abstract
Background: PAF has been implicated as a potent lipid mediator of endotoxin-induced sepsis, but its role in anthraxassociated shock is unknown. Results: Increased serum levels of PAF were present in LeTx-challenged mice. Inhibition of PAF activity prolonged survival ameliorated increased vascular permeability and hepatic necrosis. Conclusion: PAF appears to be a mediator in lethal toxin-associated damage. Significance: PAF antagonists may be helpful as adjunctive therapy for anthrax-associated shock.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 7131-7141 |
| Number of pages | 11 |
| Journal | Journal of Biological Chemistry |
| Volume | 289 |
| Issue number | 10 |
| DOIs | |
| State | Published - Mar 7 2014 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology
Fingerprint
Dive into the research topics of 'Platelet-activating factor contributes to bacillus anthracis lethal toxin-associated damage'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS