Platelet-activating factor contributes to bacillus anthracis lethal toxin-associated damage

Johanna Rivera, Rani S. Sellers, Wangyong Zeng, Nico Van Rooijen, Arturo Casadevall, David L. Goldman

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: PAF has been implicated as a potent lipid mediator of endotoxin-induced sepsis, but its role in anthraxassociated shock is unknown. Results: Increased serum levels of PAF were present in LeTx-challenged mice. Inhibition of PAF activity prolonged survival ameliorated increased vascular permeability and hepatic necrosis. Conclusion: PAF appears to be a mediator in lethal toxin-associated damage. Significance: PAF antagonists may be helpful as adjunctive therapy for anthrax-associated shock.

Original languageEnglish (US)
Pages (from-to)7131-7141
Number of pages11
JournalJournal of Biological Chemistry
Issue number10
StatePublished - Mar 7 2014
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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