Plasmodium sporozoite invasion of the mosquito salivary gland

Anil Kumar Ghosh; Marcelo Jacobs-Lorena

doi:10.1016/j.mib.2009.06.010

Plasmodium sporozoite invasion of the mosquito salivary gland

Anil Kumar Ghosh
, Marcelo Jacobs-Lorena

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

About one to two million people die of malaria every year. Anopheline mosquitoes are the obligatory vectors of Plasmodium spp., the causative agent of malaria. For transmission to occur, the parasite has to undergo a complex developmental programme in the mosquito, culminating with sporozoite invasion of the salivary glands. Strong circumstantial evidence suggests that sporozoite invasion requires specific interactions and recognition between sporozoite and salivary gland proteins. Here we review recent progress towards the elucidation of invasion mechanisms.

Original language	English (US)
Pages (from-to)	394-400
Number of pages	7
Journal	Current Opinion in Microbiology
Volume	12
Issue number	4
DOIs	https://doi.org/10.1016/j.mib.2009.06.010
State	Published - Aug 2009
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Infectious Diseases

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10.1016/j.mib.2009.06.010

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title = "Plasmodium sporozoite invasion of the mosquito salivary gland",

abstract = "About one to two million people die of malaria every year. Anopheline mosquitoes are the obligatory vectors of Plasmodium spp., the causative agent of malaria. For transmission to occur, the parasite has to undergo a complex developmental programme in the mosquito, culminating with sporozoite invasion of the salivary glands. Strong circumstantial evidence suggests that sporozoite invasion requires specific interactions and recognition between sporozoite and salivary gland proteins. Here we review recent progress towards the elucidation of invasion mechanisms.",

author = "Ghosh, \{Anil Kumar\} and Marcelo Jacobs-Lorena",

note = "Funding Information: We thank Photini Sinnis and an anonymous reviewer for excellent comments that helped improve the manuscript. Work in our laboratory was supported by grants from the National Institutes of Health. ",

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AU - Jacobs-Lorena, Marcelo

N1 - Funding Information: We thank Photini Sinnis and an anonymous reviewer for excellent comments that helped improve the manuscript. Work in our laboratory was supported by grants from the National Institutes of Health.

PY - 2009/8

Y1 - 2009/8

N2 - About one to two million people die of malaria every year. Anopheline mosquitoes are the obligatory vectors of Plasmodium spp., the causative agent of malaria. For transmission to occur, the parasite has to undergo a complex developmental programme in the mosquito, culminating with sporozoite invasion of the salivary glands. Strong circumstantial evidence suggests that sporozoite invasion requires specific interactions and recognition between sporozoite and salivary gland proteins. Here we review recent progress towards the elucidation of invasion mechanisms.

AB - About one to two million people die of malaria every year. Anopheline mosquitoes are the obligatory vectors of Plasmodium spp., the causative agent of malaria. For transmission to occur, the parasite has to undergo a complex developmental programme in the mosquito, culminating with sporozoite invasion of the salivary glands. Strong circumstantial evidence suggests that sporozoite invasion requires specific interactions and recognition between sporozoite and salivary gland proteins. Here we review recent progress towards the elucidation of invasion mechanisms.

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UR - https://www.scopus.com/pages/publications/68049117073#tab=citedBy

U2 - 10.1016/j.mib.2009.06.010

DO - 10.1016/j.mib.2009.06.010

M3 - Review article

C2 - 19608457

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JF - Current Opinion in Microbiology

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ER -

Plasmodium sporozoite invasion of the mosquito salivary gland

Abstract

ASJC Scopus subject areas

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