TY - JOUR
T1 - Plasmodium sporozoite-host interactions from the dermis to the hepatocyte
AU - Ejigiri, Ijeoma
AU - Sinnis, Photini
N1 - Funding Information:
The authors would like to thank Brandy Bennett and Dr. Marcelo Jacobs-Lorena for their helpful critiques of the manuscript and to acknowledge support from the National Institutes of Health (R01 AI056840).
PY - 2009/8
Y1 - 2009/8
N2 - Sporozoites are the infective stage of the malaria parasite. They are deposited in the skin by infected Anopheles mosquitoes and must penetrate cell barriers in the skin and liver sinusoid to reach their target cell, the hepatocyte, where they enter in a vacuole and begin development into the next life cycle stage, the exoerythrocytic form. Recent advances in our understanding of sporozoite biology in the dermal inoculation site, the role of cell traversal and the mechanism by which sporozoites productively invade hepatocytes will be highlighted in this review.
AB - Sporozoites are the infective stage of the malaria parasite. They are deposited in the skin by infected Anopheles mosquitoes and must penetrate cell barriers in the skin and liver sinusoid to reach their target cell, the hepatocyte, where they enter in a vacuole and begin development into the next life cycle stage, the exoerythrocytic form. Recent advances in our understanding of sporozoite biology in the dermal inoculation site, the role of cell traversal and the mechanism by which sporozoites productively invade hepatocytes will be highlighted in this review.
UR - http://www.scopus.com/inward/record.url?scp=68049135868&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68049135868&partnerID=8YFLogxK
U2 - 10.1016/j.mib.2009.06.006
DO - 10.1016/j.mib.2009.06.006
M3 - Review article
C2 - 19608456
AN - SCOPUS:68049135868
SN - 1369-5274
VL - 12
SP - 401
EP - 407
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
IS - 4
ER -