PLASMID-MEDIATED RESISTANCE TO NALIDIXIC ACID IN SHIGELLA DYSENTERIAE TYPE 1

M. H. Munshi; Khaleda Haider; M. M. Rahaman; David A. Sack; Zia U. Ahmed; M. G. Morshed

doi:10.1016/S0140-6736(87)90957-3

PLASMID-MEDIATED RESISTANCE TO NALIDIXIC ACID IN SHIGELLA DYSENTERIAE TYPE 1

M. H. Munshi
, Khaleda Haider
, M. M. Rahaman
, David A. Sack
, Zia U. Ahmed
, M. G. Morshed

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

130 Scopus citations

Abstract

In an epidemic of shigellosis in southern Bangladesh the causal organism, Shigella dysenteriae type 1, was resistant to nalidixic acid as well as to co-trimoxazole (trimethoprimsulphamethoxazole) and ampicillin. The genes coding for resistance to nalidixic acid, but not those coding for resistance to co-trimoxazole or ampicillin, are located on a conjugative 20 megadalton plasmid. This epidemic is of particular importance because of the resistance to nalidixic acid, an antibiotic to which shigellae are seldom resistant, and because plasmids were previously thought not to mediate resistance to nalidixic acid.

Original language	English (US)
Pages (from-to)	419-421
Number of pages	3
Journal	The Lancet
Volume	330
Issue number	8556
DOIs	https://doi.org/10.1016/S0140-6736(87)90957-3
State	Published - Aug 22 1987

ASJC Scopus subject areas

General Medicine

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10.1016/S0140-6736(87)90957-3

Cite this

@article{3ec17202798a40d084ce300b054d4212,

title = "PLASMID-MEDIATED RESISTANCE TO NALIDIXIC ACID IN SHIGELLA DYSENTERIAE TYPE 1",

abstract = "In an epidemic of shigellosis in southern Bangladesh the causal organism, Shigella dysenteriae type 1, was resistant to nalidixic acid as well as to co-trimoxazole (trimethoprimsulphamethoxazole) and ampicillin. The genes coding for resistance to nalidixic acid, but not those coding for resistance to co-trimoxazole or ampicillin, are located on a conjugative 20 megadalton plasmid. This epidemic is of particular importance because of the resistance to nalidixic acid, an antibiotic to which shigellae are seldom resistant, and because plasmids were previously thought not to mediate resistance to nalidixic acid.",

author = "Munshi, \{M. H.\} and Khaleda Haider and Rahaman, \{M. M.\} and Sack, \{David A.\} and Ahmed, \{Zia U.\} and Morshed, \{M. G.\}",

note = "Funding Information: This work was supported by the International Centre for Diarrhoeal Funding Information: Disease Research, Bangladesh, and by a grant from the US Agency for International Development.",

year = "1987",

month = aug,

day = "22",

doi = "10.1016/S0140-6736(87)90957-3",

language = "English (US)",

volume = "330",

pages = "419--421",

journal = "The Lancet",

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publisher = "Elsevier B.V.",

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AU - Munshi, M. H.

AU - Haider, Khaleda

AU - Rahaman, M. M.

AU - Sack, David A.

AU - Ahmed, Zia U.

AU - Morshed, M. G.

N1 - Funding Information: This work was supported by the International Centre for Diarrhoeal Funding Information: Disease Research, Bangladesh, and by a grant from the US Agency for International Development.

PY - 1987/8/22

Y1 - 1987/8/22

N2 - In an epidemic of shigellosis in southern Bangladesh the causal organism, Shigella dysenteriae type 1, was resistant to nalidixic acid as well as to co-trimoxazole (trimethoprimsulphamethoxazole) and ampicillin. The genes coding for resistance to nalidixic acid, but not those coding for resistance to co-trimoxazole or ampicillin, are located on a conjugative 20 megadalton plasmid. This epidemic is of particular importance because of the resistance to nalidixic acid, an antibiotic to which shigellae are seldom resistant, and because plasmids were previously thought not to mediate resistance to nalidixic acid.

AB - In an epidemic of shigellosis in southern Bangladesh the causal organism, Shigella dysenteriae type 1, was resistant to nalidixic acid as well as to co-trimoxazole (trimethoprimsulphamethoxazole) and ampicillin. The genes coding for resistance to nalidixic acid, but not those coding for resistance to co-trimoxazole or ampicillin, are located on a conjugative 20 megadalton plasmid. This epidemic is of particular importance because of the resistance to nalidixic acid, an antibiotic to which shigellae are seldom resistant, and because plasmids were previously thought not to mediate resistance to nalidixic acid.

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U2 - 10.1016/S0140-6736(87)90957-3

DO - 10.1016/S0140-6736(87)90957-3

M3 - Article

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AN - SCOPUS:0023265704

SN - 0140-6736

VL - 330

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JO - The Lancet

JF - The Lancet

IS - 8556

ER -

PLASMID-MEDIATED RESISTANCE TO NALIDIXIC ACID IN SHIGELLA DYSENTERIAE TYPE 1

Abstract

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