Abstract
We report a case of thrombotic microangiopathy (TMA) diagnosed in the kidney allograft of a 59-year-old woman who had developed plasmacytoma type monomorphic posttransplant lymphoproliferative disorder (PTLD) 30 years after a simultaneous pancreas and kidney transplant. This report demonstrates a rare etiology of TMA in a kidney allograft occurring in association with PTLD-associated monoclonal gammopathy. The main teaching points are: 1) PTLD may be considered in the work-up of a new TMA in the immunosuppressed post-transplant setting, and 2) a paraprotein-associated condition should be considered as clinically relevant coexistent in a patient with TMA because paraproteins are over-represented in patients with otherwise unexplained TMAs.
Original language | English (US) |
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Journal | OBM Transplantation |
Volume | 6 |
Issue number | 2 |
DOIs | |
State | Published - Nov 2022 |
Externally published | Yes |
Keywords
- monoclonal gammopathy
- plasmapheresis
- Post-transplant lymphoproliferative disorder
- renal pathology
- thrombotic microangiopathy
- transplant
ASJC Scopus subject areas
- Surgery
- Immunology
- Biochemistry, medical
- Transplantation