Plasma virome and the risk of blood-borne infection in persons with substance use disorder

Abraham J. Kandathil; Andrea L. Cox; Kimberly Page; David Mohr; Roham Razaghi; Khalil G. Ghanem; Susan A. Tuddenham; Yu Hsiang Hsieh; Jennifer L. Evans; Kelly E. Coller; Winston Timp; David D. Celentano; Stuart C. Ray; David L. Thomas

doi:10.1038/s41467-021-26980-8

Plasma virome and the risk of blood-borne infection in persons with substance use disorder

Abraham J. Kandathil, Andrea L. Cox, Kimberly Page, David Mohr, Roham Razaghi, Khalil G. Ghanem, Susan A. Tuddenham, Yu Hsiang Hsieh, Jennifer L. Evans, Kelly E. Coller, Winston Timp, David D. Celentano, Stuart C. Ray, David L. Thomas

Research output: Contribution to journal › Article › peer-review

Abstract

There is an urgent need for innovative methods to reduce transmission of bloodborne pathogens like HIV and HCV among people who inject drugs (PWID). We investigate if PWID who acquire non-pathogenic bloodborne viruses like anelloviruses and pegiviruses might be at greater risk of acquiring a bloodborne pathogen. PWID who later acquire HCV accumulate more non-pathogenic viruses in plasma than matched controls who do not acquire HCV infection. Additionally, phylogenetic analysis of those non-pathogenic virus sequences reveals drug use networks. Here we find first in Baltimore and confirm in San Francisco that the accumulation of non-pathogenic viruses in PWID is a harbinger for subsequent acquisition of pathogenic viruses, knowledge that may guide the prioritization of the public health resources to combat HIV and HCV.

Original language	English (US)
Article number	6909
Journal	Nature communications
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41467-021-26980-8
State	Published - Dec 2021

ASJC Scopus subject areas

General Physics and Astronomy
General Chemistry
General Biochemistry, Genetics and Molecular Biology

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Kandathil, A. J., Cox, A. L., Page, K., Mohr, D., Razaghi, R., Ghanem, K. G., Tuddenham, S. A., Hsieh, Y. H., Evans, J. L., Coller, K. E., Timp, W., Celentano, D. D., Ray, S. C., & Thomas, D. L. (2021). Plasma virome and the risk of blood-borne infection in persons with substance use disorder. Nature communications, 12(1), Article 6909. https://doi.org/10.1038/s41467-021-26980-8

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abstract = "There is an urgent need for innovative methods to reduce transmission of bloodborne pathogens like HIV and HCV among people who inject drugs (PWID). We investigate if PWID who acquire non-pathogenic bloodborne viruses like anelloviruses and pegiviruses might be at greater risk of acquiring a bloodborne pathogen. PWID who later acquire HCV accumulate more non-pathogenic viruses in plasma than matched controls who do not acquire HCV infection. Additionally, phylogenetic analysis of those non-pathogenic virus sequences reveals drug use networks. Here we find first in Baltimore and confirm in San Francisco that the accumulation of non-pathogenic viruses in PWID is a harbinger for subsequent acquisition of pathogenic viruses, knowledge that may guide the prioritization of the public health resources to combat HIV and HCV.",

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AU - Ghanem, Khalil G.

AU - Tuddenham, Susan A.

AU - Hsieh, Yu Hsiang

AU - Evans, Jennifer L.

AU - Coller, Kelly E.

AU - Timp, Winston

AU - Celentano, David D.

AU - Ray, Stuart C.

AU - Thomas, David L.

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AB - There is an urgent need for innovative methods to reduce transmission of bloodborne pathogens like HIV and HCV among people who inject drugs (PWID). We investigate if PWID who acquire non-pathogenic bloodborne viruses like anelloviruses and pegiviruses might be at greater risk of acquiring a bloodborne pathogen. PWID who later acquire HCV accumulate more non-pathogenic viruses in plasma than matched controls who do not acquire HCV infection. Additionally, phylogenetic analysis of those non-pathogenic virus sequences reveals drug use networks. Here we find first in Baltimore and confirm in San Francisco that the accumulation of non-pathogenic viruses in PWID is a harbinger for subsequent acquisition of pathogenic viruses, knowledge that may guide the prioritization of the public health resources to combat HIV and HCV.

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Plasma virome and the risk of blood-borne infection in persons with substance use disorder

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ASJC Scopus subject areas

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