Plasma Proteomic Analysis Reveals Age-Specific Changes in Platelet- and Endothelial Cell–Derived Proteins and Regulators of Plasma Coagulation and Fibrinolysis

Conor McCafferty; Xavier Busuttil-Crellin; Tengyi Cai; Paul Monagle; Neil A. Goldenberg; Vera Ignjatovic

doi:10.1016/j.jpeds.2020.01.051

Plasma Proteomic Analysis Reveals Age-Specific Changes in Platelet- and Endothelial Cell–Derived Proteins and Regulators of Plasma Coagulation and Fibrinolysis

Conor McCafferty
, Xavier Busuttil-Crellin
, Tengyi Cai
, Paul Monagle
, Neil A. Goldenberg
, Vera Ignjatovic

School of Medicine

Research output: Contribution to journal › Comment/debate › peer-review

2 Scopus citations

Abstract

This post hoc study of a plasma proteomic database investigated hemostatic proteins in the context of developmental hemostasis. Twenty-seven hemostatic proteins changed expression with age, and the hemostatic profile of neonates was unique. Appreciating developmental hemostasis through proteomics may lead to more personalized medicine for hospitalized children.

Original language	English (US)
Pages (from-to)	S29-S36
Journal	Journal of Pediatrics
Volume	221
DOIs	https://doi.org/10.1016/j.jpeds.2020.01.051
State	Published - Jun 2020

Keywords

hemostasis
pediatrics
plasma
platelet
proteomics

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/j.jpeds.2020.01.051

Cite this

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title = "Plasma Proteomic Analysis Reveals Age-Specific Changes in Platelet- and Endothelial Cell{\textendash}Derived Proteins and Regulators of Plasma Coagulation and Fibrinolysis",

abstract = "This post hoc study of a plasma proteomic database investigated hemostatic proteins in the context of developmental hemostasis. Twenty-seven hemostatic proteins changed expression with age, and the hemostatic profile of neonates was unique. Appreciating developmental hemostasis through proteomics may lead to more personalized medicine for hospitalized children.",

keywords = "hemostasis, pediatrics, plasma, platelet, proteomics",

author = "Conor McCafferty and Xavier Busuttil-Crellin and Tengyi Cai and Paul Monagle and Goldenberg, \{Neil A.\} and Vera Ignjatovic",

note = "Funding Information: We thank members of the Anesthesia and Surgical Departments of the Royal Children's Hospital for facilitation of sample collection. Publication of this supplement was supported by the Johns Hopkins All Children's Foundation. Funding Information: Supported by the Victorian Government's Operational Infrastructure Support Program. Bioplatforms Australia Ltd, facilitated access to the Australian Proteome Analysis Facility, which is in turn supported by the Australian Government's National Collaborative Research Infrastructure Scheme. The authors declare no conflicts of interest. Funding Information: Publication of this supplement was supported by the Johns Hopkins All Children's Foundation. Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = jun,

doi = "10.1016/j.jpeds.2020.01.051",

language = "English (US)",

volume = "221",

pages = "S29--S36",

journal = "Journal of Pediatrics",

issn = "0022-3476",

publisher = "Elsevier Inc.",

}

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T1 - Plasma Proteomic Analysis Reveals Age-Specific Changes in Platelet- and Endothelial Cell–Derived Proteins and Regulators of Plasma Coagulation and Fibrinolysis

AU - McCafferty, Conor

AU - Busuttil-Crellin, Xavier

AU - Cai, Tengyi

AU - Monagle, Paul

AU - Goldenberg, Neil A.

AU - Ignjatovic, Vera

N1 - Funding Information: We thank members of the Anesthesia and Surgical Departments of the Royal Children's Hospital for facilitation of sample collection. Publication of this supplement was supported by the Johns Hopkins All Children's Foundation. Funding Information: Supported by the Victorian Government's Operational Infrastructure Support Program. Bioplatforms Australia Ltd, facilitated access to the Australian Proteome Analysis Facility, which is in turn supported by the Australian Government's National Collaborative Research Infrastructure Scheme. The authors declare no conflicts of interest. Funding Information: Publication of this supplement was supported by the Johns Hopkins All Children's Foundation. Publisher Copyright: © 2020

PY - 2020/6

Y1 - 2020/6

N2 - This post hoc study of a plasma proteomic database investigated hemostatic proteins in the context of developmental hemostasis. Twenty-seven hemostatic proteins changed expression with age, and the hemostatic profile of neonates was unique. Appreciating developmental hemostasis through proteomics may lead to more personalized medicine for hospitalized children.

AB - This post hoc study of a plasma proteomic database investigated hemostatic proteins in the context of developmental hemostasis. Twenty-seven hemostatic proteins changed expression with age, and the hemostatic profile of neonates was unique. Appreciating developmental hemostasis through proteomics may lead to more personalized medicine for hospitalized children.

KW - hemostasis

KW - pediatrics

KW - plasma

KW - platelet

KW - proteomics

UR - https://www.scopus.com/pages/publications/85085215640

UR - https://www.scopus.com/pages/publications/85085215640#tab=citedBy

U2 - 10.1016/j.jpeds.2020.01.051

DO - 10.1016/j.jpeds.2020.01.051

M3 - Comment/debate

C2 - 32482231

AN - SCOPUS:85085215640

SN - 0022-3476

VL - 221

SP - S29-S36

JO - Journal of Pediatrics

JF - Journal of Pediatrics

ER -

Plasma Proteomic Analysis Reveals Age-Specific Changes in Platelet- and Endothelial Cell–Derived Proteins and Regulators of Plasma Coagulation and Fibrinolysis

Abstract

Keywords

ASJC Scopus subject areas

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