Plasma proteome database

Malabika Sarker; G. Hanumanthu; Akhilesh Pandey

doi:10.1007/978-1-59745-432-2_6

Plasma proteome database

Malabika Sarker, G. Hanumanthu, Akhilesh Pandey

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

The plasma proteome is one of the most important proteomes from a diagnostic standpoint, as quantitative changes between normal and diseased states can be used to discover novel biomarkers for clinical diagnosis and therapeutic monitoring of diseases. HUPO's Plasma Proteome Project has involved characterization of the plasma proteome by an international consortium using technologies ranging from antibody arrays to mass spectrometry and has helped in the construction of a substantial catalog of plasma proteins. Our group has developed the Plasma Proteome Database (http://www.plasmaproteomedatabase.org) as a comprehensive resource of annotated data for posttranslational modifications, single-nucleotide polymorphisms, tissue expression, subcellular localization, and disease involvement of plasma proteins. This database should serve to facilitate further research to help understand the plasma proteome in health and disease.

Original language	English (US)
Title of host publication	Proteomics of Human Body Fluids: Principles, Methods, and Applications
Publisher	Humana Press Inc.
Pages	129-136
Number of pages	8
ISBN (Print)	9781597454322, 9781588296573
DOIs	https://doi.org/10.1007/978-1-59745-432-2_6
State	Published - 2007

Keywords

annotation
bioinformatics
database
mass spectrometry
plasma
Proteomics

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/978-1-59745-432-2_6

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AU - Hanumanthu, G.

AU - Pandey, Akhilesh

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AB - The plasma proteome is one of the most important proteomes from a diagnostic standpoint, as quantitative changes between normal and diseased states can be used to discover novel biomarkers for clinical diagnosis and therapeutic monitoring of diseases. HUPO's Plasma Proteome Project has involved characterization of the plasma proteome by an international consortium using technologies ranging from antibody arrays to mass spectrometry and has helped in the construction of a substantial catalog of plasma proteins. Our group has developed the Plasma Proteome Database (http://www.plasmaproteomedatabase.org) as a comprehensive resource of annotated data for posttranslational modifications, single-nucleotide polymorphisms, tissue expression, subcellular localization, and disease involvement of plasma proteins. This database should serve to facilitate further research to help understand the plasma proteome in health and disease.

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KW - bioinformatics

KW - database

KW - mass spectrometry

KW - plasma

KW - Proteomics

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BT - Proteomics of Human Body Fluids: Principles, Methods, and Applications

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Plasma proteome database

Abstract

Keywords

ASJC Scopus subject areas

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