Plasma nitrite response in older women to a physical function test

Devon A. Dobrosielski, Tennille Presley, Andreas Perlegas, Anthony P. Marsh, Daniel Kim-Shapiro, W. Jack Rejeski

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background and aims: Nitric oxide (NO) may play a critical role in facilitating the delivery of blood to active skeletal muscle, ultimately impacting functional health in older adults. Plasma nitrite is a useful marker of vascular NO bioavailability. The aim of the current investigation was to examine the effect of a widely used physical function test on plasma nitrite concentrations in older adults. Methods: Venous blood was drawn before, immediately following, and 10 minutes following the completion of a 400-m walk test. Blood samples were added to heparin and frozen for subsequent analysis of nitrite levels using chemiluminescence. Results: Twenty six (79±4 yrs) women participated in this study. Plasma nitrite levels decreased approximately 22% from baseline following a 400-m walk. Percent change in plasma nitrite was related to walking speed (r=-0.550, p=0.004). Conclusions: These data suggest an alteration in plasma nitrite concentration following a functional test which may impact functional health.

Original languageEnglish (US)
Pages (from-to)383-386
Number of pages4
JournalAging Clinical and Experimental Research
Issue number5-6
StatePublished - Oct 2010


  • 400 Meter walk
  • Acute exercise
  • Nitric oxide
  • Plasma nitrite

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology


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