Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda

Ravell Juan; Isaac Otim; Hadijah Nabalende; Ismail D. Legason; Steven J. Reynolds; Martin D. Ogwang; Christopher M. Ndugwa; Vickie Marshall; Denise Whitby; James J. Goedert; Eric A. Engels; Kishor Bhatia; Michael J. Lenardo; Sam M. Mbulaiteye

doi:10.1016/j.canep.2017.12.004

Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda

Ravell Juan, Isaac Otim, Hadijah Nabalende, Ismail D. Legason, Steven J. Reynolds, Martin D. Ogwang, Christopher M. Ndugwa, Vickie Marshall, Denise Whitby, James J. Goedert, Eric A. Engels, Kishor Bhatia, Michael J. Lenardo, Sam M. Mbulaiteye

School of Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Background Epstein-Barr virus (EBV) causes endemic Burkitt lymphoma (eBL). EBV control was improved by magnesium (Mg²⁺) supplementation in XMEN, an X-linked genetic disease associated with Mg²⁺ deficiency, high circulating EBV levels (viral loads), and EBV-related lymphomas. We, therefore, investigated the relationship between Mg²⁺ levels and EBV levels and eBL in Uganda. Methods Plasma Mg²⁺ was measured in 45 women with low or high circulating EBV levels, 40 pediatric eBL cases, and 79 healthy children. Mg²⁺ uptake by T-lymphocytes was evaluated in samples from healthy donors. Results Plasma Mg²⁺ deficiency (plasma level <1.8 mg/dl) was more likely in women with high- vs. low-EBV levels (76.0% vs. 35%; odds ratio [OR] 11.3, 95% CI 2.14–60.2), controlling for age, and in eBL cases than controls (42.0% vs. 13.9%; OR 3.61, 95% CI 1.32–9.88), controlling for sex, age group, and malaria status. Mg²⁺ uptake by T-lymphocytes was related to extracellular Mg²⁺ concentration. Interpretation Plasma Mg²⁺ deficiency is associated with high EBV levels and eBL.

Original language	English (US)
Pages (from-to)	70-74
Number of pages	5
Journal	Cancer Epidemiology
Volume	52
DOIs	https://doi.org/10.1016/j.canep.2017.12.004
State	Published - Feb 2018

Keywords

Africa
Burkitt lymphoma
Epidemiology
Epstein-Barr virus
Magnesium
XMEN

ASJC Scopus subject areas

Epidemiology
Oncology
Cancer Research

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Juan, R., Otim, I., Nabalende, H., Legason, I. D., Reynolds, S. J., Ogwang, M. D., Ndugwa, C. M., Marshall, V., Whitby, D., Goedert, J. J., Engels, E. A., Bhatia, K., Lenardo, M. J., & Mbulaiteye, S. M. (2018). Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda. Cancer Epidemiology, 52, 70-74. https://doi.org/10.1016/j.canep.2017.12.004

Juan, R, Otim, I, Nabalende, H, Legason, ID, Reynolds, SJ, Ogwang, MD, Ndugwa, CM, Marshall, V, Whitby, D, Goedert, JJ, Engels, EA, Bhatia, K, Lenardo, MJ & Mbulaiteye, SM 2018, 'Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda', Cancer Epidemiology, vol. 52, pp. 70-74. https://doi.org/10.1016/j.canep.2017.12.004

@article{9c9162b4d9da4c099b79606c26e0b6de,

title = "Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda",

abstract = "Background Epstein-Barr virus (EBV) causes endemic Burkitt lymphoma (eBL). EBV control was improved by magnesium (Mg2+) supplementation in XMEN, an X-linked genetic disease associated with Mg2+ deficiency, high circulating EBV levels (viral loads), and EBV-related lymphomas. We, therefore, investigated the relationship between Mg2+ levels and EBV levels and eBL in Uganda. Methods Plasma Mg2+ was measured in 45 women with low or high circulating EBV levels, 40 pediatric eBL cases, and 79 healthy children. Mg2+ uptake by T-lymphocytes was evaluated in samples from healthy donors. Results Plasma Mg2+ deficiency (plasma level <1.8 mg/dl) was more likely in women with high- vs. low-EBV levels (76.0% vs. 35%; odds ratio [OR] 11.3, 95% CI 2.14–60.2), controlling for age, and in eBL cases than controls (42.0% vs. 13.9%; OR 3.61, 95% CI 1.32–9.88), controlling for sex, age group, and malaria status. Mg2+ uptake by T-lymphocytes was related to extracellular Mg2+ concentration. Interpretation Plasma Mg2+ deficiency is associated with high EBV levels and eBL.",

keywords = "Africa, Burkitt lymphoma, Epidemiology, Epstein-Barr virus, Magnesium, XMEN",

author = "Ravell Juan and Isaac Otim and Hadijah Nabalende and Legason, {Ismail D.} and Reynolds, {Steven J.} and Ogwang, {Martin D.} and Ndugwa, {Christopher M.} and Vickie Marshall and Denise Whitby and Goedert, {James J.} and Engels, {Eric A.} and Kishor Bhatia and Lenardo, {Michael J.} and Mbulaiteye, {Sam M.}",

note = "Funding Information: The study was funded by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics , National Cancer Institute (NCI) (Contracts HHSN261201100063C , HHSN261201100007I , and HHSN261200800001E ) and, in part, by the Intramural Research Program, National Institute of Allergy and Infectious Diseases (SJR) , National Institutes of Health, Department of Health and Human Services . The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. The content of this manuscript is the sole responsibility of the authors. Publisher Copyright: {\textcopyright} 2017",

year = "2018",

month = feb,

doi = "10.1016/j.canep.2017.12.004",

language = "English (US)",

volume = "52",

pages = "70--74",

journal = "Cancer Epidemiology",

issn = "1877-7821",

publisher = "Elsevier BV",

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TY - JOUR

T1 - Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda

AU - Juan, Ravell

AU - Otim, Isaac

AU - Nabalende, Hadijah

AU - Legason, Ismail D.

AU - Reynolds, Steven J.

AU - Ogwang, Martin D.

AU - Ndugwa, Christopher M.

AU - Marshall, Vickie

AU - Whitby, Denise

AU - Goedert, James J.

AU - Engels, Eric A.

AU - Bhatia, Kishor

AU - Lenardo, Michael J.

AU - Mbulaiteye, Sam M.

N1 - Funding Information: The study was funded by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics , National Cancer Institute (NCI) (Contracts HHSN261201100063C , HHSN261201100007I , and HHSN261200800001E ) and, in part, by the Intramural Research Program, National Institute of Allergy and Infectious Diseases (SJR) , National Institutes of Health, Department of Health and Human Services . The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. The content of this manuscript is the sole responsibility of the authors. Publisher Copyright: © 2017

PY - 2018/2

Y1 - 2018/2

N2 - Background Epstein-Barr virus (EBV) causes endemic Burkitt lymphoma (eBL). EBV control was improved by magnesium (Mg2+) supplementation in XMEN, an X-linked genetic disease associated with Mg2+ deficiency, high circulating EBV levels (viral loads), and EBV-related lymphomas. We, therefore, investigated the relationship between Mg2+ levels and EBV levels and eBL in Uganda. Methods Plasma Mg2+ was measured in 45 women with low or high circulating EBV levels, 40 pediatric eBL cases, and 79 healthy children. Mg2+ uptake by T-lymphocytes was evaluated in samples from healthy donors. Results Plasma Mg2+ deficiency (plasma level <1.8 mg/dl) was more likely in women with high- vs. low-EBV levels (76.0% vs. 35%; odds ratio [OR] 11.3, 95% CI 2.14–60.2), controlling for age, and in eBL cases than controls (42.0% vs. 13.9%; OR 3.61, 95% CI 1.32–9.88), controlling for sex, age group, and malaria status. Mg2+ uptake by T-lymphocytes was related to extracellular Mg2+ concentration. Interpretation Plasma Mg2+ deficiency is associated with high EBV levels and eBL.

AB - Background Epstein-Barr virus (EBV) causes endemic Burkitt lymphoma (eBL). EBV control was improved by magnesium (Mg2+) supplementation in XMEN, an X-linked genetic disease associated with Mg2+ deficiency, high circulating EBV levels (viral loads), and EBV-related lymphomas. We, therefore, investigated the relationship between Mg2+ levels and EBV levels and eBL in Uganda. Methods Plasma Mg2+ was measured in 45 women with low or high circulating EBV levels, 40 pediatric eBL cases, and 79 healthy children. Mg2+ uptake by T-lymphocytes was evaluated in samples from healthy donors. Results Plasma Mg2+ deficiency (plasma level <1.8 mg/dl) was more likely in women with high- vs. low-EBV levels (76.0% vs. 35%; odds ratio [OR] 11.3, 95% CI 2.14–60.2), controlling for age, and in eBL cases than controls (42.0% vs. 13.9%; OR 3.61, 95% CI 1.32–9.88), controlling for sex, age group, and malaria status. Mg2+ uptake by T-lymphocytes was related to extracellular Mg2+ concentration. Interpretation Plasma Mg2+ deficiency is associated with high EBV levels and eBL.

KW - Africa

KW - Burkitt lymphoma

KW - Epidemiology

KW - Epstein-Barr virus

KW - Magnesium

KW - XMEN

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UR - http://www.scopus.com/inward/citedby.url?scp=85038022583&partnerID=8YFLogxK

U2 - 10.1016/j.canep.2017.12.004

DO - 10.1016/j.canep.2017.12.004

M3 - Article

C2 - 29248801

AN - SCOPUS:85038022583

SN - 1877-7821

VL - 52

SP - 70

EP - 74

JO - Cancer Epidemiology

JF - Cancer Epidemiology

ER -

Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda

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