Plasma levels of trazodone: Methodology and applications

D. R. Abernethy; D. J. Greenblatt; R. I. Shader

doi:10.1159/000137941

Plasma levels of trazodone: Methodology and applications

D. R. Abernethy, D. J. Greenblatt, R. I. Shader

School of Medicine

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17 Scopus citations

Abstract

A sensitive (to 5.0 ng/ml) and specific method for analysis of the antidepressant trazodone is described. The method utilizes gas-liquid chromatography with nitrogen-phosphorus detection. Applicability of the method is demonstrated by (1) a pharmacokinetic study in a normal volunteer who received 50 mg trazodone orally and (2) steady-state plasma level determinations of 2 patients receiving trazodone in the treatment of depression.

Original language	English (US)
Pages (from-to)	42-46
Number of pages	5
Journal	Pharmacology
Volume	28
Issue number	1
DOIs	https://doi.org/10.1159/000137941
State	Published - 1984

ASJC Scopus subject areas

Pharmacology

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10.1159/000137941

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title = "Plasma levels of trazodone: Methodology and applications",

abstract = "A sensitive (to 5.0 ng/ml) and specific method for analysis of the antidepressant trazodone is described. The method utilizes gas-liquid chromatography with nitrogen-phosphorus detection. Applicability of the method is demonstrated by (1) a pharmacokinetic study in a normal volunteer who received 50 mg trazodone orally and (2) steady-state plasma level determinations of 2 patients receiving trazodone in the treatment of depression.",

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AB - A sensitive (to 5.0 ng/ml) and specific method for analysis of the antidepressant trazodone is described. The method utilizes gas-liquid chromatography with nitrogen-phosphorus detection. Applicability of the method is demonstrated by (1) a pharmacokinetic study in a normal volunteer who received 50 mg trazodone orally and (2) steady-state plasma level determinations of 2 patients receiving trazodone in the treatment of depression.

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Plasma levels of trazodone: Methodology and applications

Abstract

ASJC Scopus subject areas

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