TY - JOUR
T1 - Plasma Klotho and Frailty in Older Adults
T2 - Findings from the InCHIANTI Study
AU - Shardell, Michelle
AU - Semba, Richard D.
AU - Kalyani, Rita R.
AU - Bandinelli, Stefania
AU - Prather, Aric A.
AU - Chia, Chee W.
AU - Ferrucci, Luigi
N1 - Publisher Copyright:
© The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.
PY - 2019/6/18
Y1 - 2019/6/18
N2 - Background: The hormone klotho, encoded by the gene klotho, is primarily expressed in the kidney and choroid plexus of the brain. Higher klotho concentrations have been linked to better physical performance; however, it is unknown whether klotho relates to frailty status in older adults. Methods: Plasma klotho was measured in 774 participants aged ≤65 years enrolled in InCHIANTI, a prospective cohort study comprising Italian adults. Frailty status was assessed at 3 and 6 years after enrollment. Frailty was defined as presence of at least three out of five criteria of unintentional weight loss, exhaustion, sedentariness, muscle weakness, and slow walking speed; prefrailty was defined as presence of one or two criteria; and robustness was defined as zero criteria. We assessed whether plasma klotho concentrations measured at the 3-year visit related to frailty. Results: Each additional natural logarithm of klotho (pg/mL) was associated with lower odds of frailty versus robustness after adjustment for covariates (odds ratio [OR] 0.46; 95% confidence interval 0.21, 0.98; p-value =.045). Higher klotho was particularly associated with lower odds of exhaustion (OR 0.57; 95% CI 0.36, 0.89; p-value =.014). Participants with higher klotho also had lower estimated odds of weight loss and weakness, but these findings were not statistically significant. Conclusions: Higher plasma klotho concentrations were associated with lower likelihoods of frailty and particularly exhaustion. Future studies should investigate modifiable mechanisms through which klotho may affect the frailty syndrome.
AB - Background: The hormone klotho, encoded by the gene klotho, is primarily expressed in the kidney and choroid plexus of the brain. Higher klotho concentrations have been linked to better physical performance; however, it is unknown whether klotho relates to frailty status in older adults. Methods: Plasma klotho was measured in 774 participants aged ≤65 years enrolled in InCHIANTI, a prospective cohort study comprising Italian adults. Frailty status was assessed at 3 and 6 years after enrollment. Frailty was defined as presence of at least three out of five criteria of unintentional weight loss, exhaustion, sedentariness, muscle weakness, and slow walking speed; prefrailty was defined as presence of one or two criteria; and robustness was defined as zero criteria. We assessed whether plasma klotho concentrations measured at the 3-year visit related to frailty. Results: Each additional natural logarithm of klotho (pg/mL) was associated with lower odds of frailty versus robustness after adjustment for covariates (odds ratio [OR] 0.46; 95% confidence interval 0.21, 0.98; p-value =.045). Higher klotho was particularly associated with lower odds of exhaustion (OR 0.57; 95% CI 0.36, 0.89; p-value =.014). Participants with higher klotho also had lower estimated odds of weight loss and weakness, but these findings were not statistically significant. Conclusions: Higher plasma klotho concentrations were associated with lower likelihoods of frailty and particularly exhaustion. Future studies should investigate modifiable mechanisms through which klotho may affect the frailty syndrome.
KW - Biomarkers
KW - Endocrinology
KW - Epidemiology
KW - Frailty syndrome
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U2 - 10.1093/gerona/glx202
DO - 10.1093/gerona/glx202
M3 - Article
C2 - 29053774
AN - SCOPUS:85068401853
SN - 1079-5006
VL - 74
SP - 1052
EP - 1058
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 7
ER -