TY - JOUR
T1 - Plasma homocysteine levels associated with a corrected QT interval
AU - Li, Zhao
AU - Guo, Xiaofan
AU - Sun, Guozhe
AU - Zheng, Liqiang
AU - Sun, Yingxian
AU - Liu, Yamin
AU - Abraham, Maria Roselle
N1 - Funding Information:
This study was supported by grant from the “Twelfth Five-Year” project funds (National Science and Technology Support Program of China, Grant No. 2012BAJ18B02) and the fund assisted in data collection. This study was also supported by grant from the Natural Science Foundation of Liaoning Province (2013021090) and the fund assisted in manuscript writing.
Publisher Copyright:
© 2017 The Author(s).
PY - 2017/7/11
Y1 - 2017/7/11
N2 - Background: Little is known about the relationship between homocysteine (Hcy) levels and the QT interval. We examined the association of different Hcy levels with corrected QT (QTc) intervals in a general population. Methods: Plasma levels of Hcy were assessed in a population-based study of 7002 participants 35 years of age and older from 2012 to 2013. Twelve-lead ECGs were performed on all participants and analyzed automatically. Results: The distribution of Hcy levels was determined for an entire population after the data were grouped into quartiles (Q1: <=11.1umol/L; Q2: 11.1-13.8umol/L; Q3: 13.8-18.2 umol/L; Q4 > 18.2 umol/L). The mean value of the QTc interval in each quartile was 433.2 ± 23.8 ms, 430.0 ± 24.6 ms, 429.2 ± 24.5 ms and 430.6 ± 25.7 ms. Multiple logistic regression analyses showed that, compared with the second quartile, and after fully adjusting for potential confounding factors, the odds for QTc > 440 ms in the first and fourth quartile increased (P < 0.05), (OR: 1.23, 95% CI: 1.05-1.43 for Q1; OR: 1.40, 95% CI: 1.19-1.65 for Q4). Conclusions: QTc interval was associated with the Hcy level in this general population.
AB - Background: Little is known about the relationship between homocysteine (Hcy) levels and the QT interval. We examined the association of different Hcy levels with corrected QT (QTc) intervals in a general population. Methods: Plasma levels of Hcy were assessed in a population-based study of 7002 participants 35 years of age and older from 2012 to 2013. Twelve-lead ECGs were performed on all participants and analyzed automatically. Results: The distribution of Hcy levels was determined for an entire population after the data were grouped into quartiles (Q1: <=11.1umol/L; Q2: 11.1-13.8umol/L; Q3: 13.8-18.2 umol/L; Q4 > 18.2 umol/L). The mean value of the QTc interval in each quartile was 433.2 ± 23.8 ms, 430.0 ± 24.6 ms, 429.2 ± 24.5 ms and 430.6 ± 25.7 ms. Multiple logistic regression analyses showed that, compared with the second quartile, and after fully adjusting for potential confounding factors, the odds for QTc > 440 ms in the first and fourth quartile increased (P < 0.05), (OR: 1.23, 95% CI: 1.05-1.43 for Q1; OR: 1.40, 95% CI: 1.19-1.65 for Q4). Conclusions: QTc interval was associated with the Hcy level in this general population.
KW - Cardiovascular disease
KW - Corrected QT interval
KW - Homocysteine
KW - Metabolic syndrome
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U2 - 10.1186/s12872-017-0617-z
DO - 10.1186/s12872-017-0617-z
M3 - Article
C2 - 28693429
AN - SCOPUS:85026306013
SN - 1471-2261
VL - 17
JO - BMC Cardiovascular Disorders
JF - BMC Cardiovascular Disorders
IS - 1
M1 - 182
ER -