Abstract
A 12-year-old boy with HbSS sickle cell disease (SCD) was admitted with an acute febrile illness and developed overt stroke 3 days later. Plasma glial fibrillary acidic protein levels were elevated, as compared to pediatric controls, 32 h prior to the clinical diagnosis of stroke, peaked immediately prior to the exchange transfusion, and remained elevated 1 year later despite chronic transfusion therapy. Stroke in SCD can occur in the setting of acute illness, and a biomarker that could predict the onset and triage ill children to therapeutic intervention more quickly would be useful.
Original language | English (US) |
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Pages (from-to) | 103-106 |
Number of pages | 4 |
Journal | Acta haematologica |
Volume | 125 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2011 |
Keywords
- Chronic transfusion
- Glial fibrillary acidic protein
- Sickle cell
- Stroke
ASJC Scopus subject areas
- Hematology