Original language | English (US) |
---|---|
Pages (from-to) | 668-671 |
Number of pages | 4 |
Journal | The Journal of pediatrics |
Volume | 109 |
Issue number | 4 |
DOIs | |
State | Published - Oct 1986 |
Externally published | Yes |
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
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In: The Journal of pediatrics, Vol. 109, No. 4, 10.1986, p. 668-671.
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Plasma amino acid levels after single-dose aspartame consumption in phenylketonuria, mild hyperphenylalaninemia, and heterozygous state for phenylketonuria
AU - Caballero, Benjamin
AU - Mahon, Barbara E.
AU - Rohr, Frances J.
AU - Levy, Harvey L.
AU - Wurtman, Richard J.
N1 - Funding Information: Aspartame (N-aspartyl-phenylalanine methyl ester), a widely used artificial sweetener, is hydrolyzed in the intestinal lumen to methanol and to its constituent amino acids phenylalanine and aspartic acid. Ingestion of this sweetener causes a sharp increase in plasma phenylalanine levels in normal persons a and in patients with phenylketonuria? The label on aspartame-containing products includes a warning to patients with PKU, but no information on the actual sweetener content, and there is concern that aspartame ingestion by those who do not have PKU could produce phenylalanine levels sufficiently high to harm the brain, especially among the estimated 2% of the general population who carry the gene for PKU and thus have a reduced capacity for phenylalanine metabolism. Studies in rats show that elevations of plasma phenytalanine levels, as Supported in part by Grants NS 21231 and NS 05096 from the National Institute of Neurological, Communicative Diseases, and Stroke, the Center for Brain Sciences and Metabolism Charitable Trust, and by Grant MCJ-250501 from the Division of Maternal and Child Health, Department of Health and Human Services. Submitted for publication Jan. 20, 1986; accepted May 13, 1986. Reprint requests: B. Caballero, M.D., Rm. E17-445, MIT, Cambridge, MA 02139.
PY - 1986/10
Y1 - 1986/10
UR - http://www.scopus.com/inward/record.url?scp=0022889245&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022889245&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(86)80239-6
DO - 10.1016/S0022-3476(86)80239-6
M3 - Article
C2 - 3761084
AN - SCOPUS:0022889245
SN - 0022-3476
VL - 109
SP - 668
EP - 671
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 4
ER -