TY - JOUR
T1 - Plasma adipokines, bone mass, and hip geometry in rural Chinese adolescents
AU - Hong, Xiumei
AU - Arguelles, Lester M.
AU - Tsai, Hui Ju
AU - Zhang, Shanchun
AU - Wang, Guoying
AU - Wang, Binyan
AU - Liu, Xue
AU - Li, Zhiping
AU - Tang, Genfu
AU - Xing, Houxun
AU - Xu, Xiping
AU - Wang, Xiaobin
N1 - Funding Information:
This work was supported by Grants R01 HD049059 from the National Institute of Child Health and Human Development , R01 HL0864619 from the National Heart, Lung, and Blood Institute , R01 AG032227 from the National Institute of Aging , and 30700880 from the Chinese Science Foundation .
PY - 2010/4
Y1 - 2010/4
N2 - Context: Adipokines have been linked to bone phenotypes recently, but with conflicting results. Few such studies have been conducted in adolescents. Objective:The aim of the study was to examine the associations of adiponectin and leptin with multiple bone phenotypes in Chinese adolescents and estimate the genetic contribution to these associations. Design and Setting: This was a cross-sectional study conducted in rural China. Participants: A total of 675 males and 575 females aged 13-21 yr were included. Outcome Measures: Fat mass (FM), lean mass (LM), bone area (BA), bone mineral content (BMC), cross-sectional area (CSA), and section modulus (SM) were measured by dual-energy x-ray absorptiometry. Plasma adipokine concentration was determined using sandwich immunoassays. Results: Adiponectin was inversely associated with all BMCs in males (P < 0.01), but not in females, after adjusting for LM, body weight, or BMI singly, or for LM and FM simultaneously. No such relationships were observed for CSA or SM in both genders. Leptin was inversely associated with all BAs, total-hip BMC, CSA, and SM in both genders, when adjusting for body weight or BMI. These associations, except for whole-body BA and lumbar spine BA in females, disappeared when simultaneously adjusting for LM and FM. By Cholesky decomposition models using twin design, significant genetic correlations were detected between adiponectin and total-hip BMC in males and between leptin and total-hip BMC in both genders. Conclusions: We demonstrated that adiponectin and leptin were inversely associated with adolescent bone phenotypes but showed differential associations by gender, type of bone phenotypes, and adjustment of FM. This study also suggested that adipokines and bone phenotypes may share a common set of genes.
AB - Context: Adipokines have been linked to bone phenotypes recently, but with conflicting results. Few such studies have been conducted in adolescents. Objective:The aim of the study was to examine the associations of adiponectin and leptin with multiple bone phenotypes in Chinese adolescents and estimate the genetic contribution to these associations. Design and Setting: This was a cross-sectional study conducted in rural China. Participants: A total of 675 males and 575 females aged 13-21 yr were included. Outcome Measures: Fat mass (FM), lean mass (LM), bone area (BA), bone mineral content (BMC), cross-sectional area (CSA), and section modulus (SM) were measured by dual-energy x-ray absorptiometry. Plasma adipokine concentration was determined using sandwich immunoassays. Results: Adiponectin was inversely associated with all BMCs in males (P < 0.01), but not in females, after adjusting for LM, body weight, or BMI singly, or for LM and FM simultaneously. No such relationships were observed for CSA or SM in both genders. Leptin was inversely associated with all BAs, total-hip BMC, CSA, and SM in both genders, when adjusting for body weight or BMI. These associations, except for whole-body BA and lumbar spine BA in females, disappeared when simultaneously adjusting for LM and FM. By Cholesky decomposition models using twin design, significant genetic correlations were detected between adiponectin and total-hip BMC in males and between leptin and total-hip BMC in both genders. Conclusions: We demonstrated that adiponectin and leptin were inversely associated with adolescent bone phenotypes but showed differential associations by gender, type of bone phenotypes, and adjustment of FM. This study also suggested that adipokines and bone phenotypes may share a common set of genes.
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U2 - 10.1210/jc.2009-1726
DO - 10.1210/jc.2009-1726
M3 - Article
C2 - 20147582
AN - SCOPUS:77951648578
SN - 0021-972X
VL - 95
SP - 1644
EP - 1652
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 4
ER -