Pituitary adenomas: historical perspective, surgical management and future directions

Debebe Theodros, Mira Patel, Jacob Ruzevick, Michael Lim, Chetan Bettegowda

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Pituitary adenomas are among the most common central nervous system tumors. They represent a diverse group of neoplasms that may or may not secrete hormones based on their cell of origin. Epidemiologic studies have documented the incidence of pituitary adenomas within the general population to be as high as 16.7%. A growing body of work has helped to elucidate the pathogenesis of these tumors. Each subtype has been shown to demonstrate unique cellular changes potentially leading to tumorigenesis. Surgical advancements over several decades have included microsurgery and the employment of the endoscope for surgical resection. These advancements increase the likelihood of gross-total resection and have resulted in decreased patient morbidity.

Original languageEnglish (US)
Pages (from-to)411-429
Number of pages19
JournalCNS oncology
Issue number6
StatePublished - 2015


  • microsurgery
  • pituitary adenomas
  • transsphenoidal surgery

ASJC Scopus subject areas

  • General Medicine


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