PIRPLE: A penalized-likelihood framework for incorporation of prior images in CT reconstruction

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39 Scopus citations


Over the course of diagnosis and treatment, it is common for a number of imaging studies to be acquired. Such imaging sequences can provide substantial patient-specific prior knowledge about the anatomy that can be incorporated into a prior-image-based tomographic reconstruction for improved image quality and better dose utilization. We present a general methodology using a model-based reconstruction approach including formulations of the measurement noise that also integrates prior images. This penalized-likelihood technique adopts a sparsity enforcing penalty that incorporates prior information yet allows for change between the current reconstruction and the prior image. Moreover, since prior images are generally not registered with the current image volume, we present a modified model-based approach that seeks a joint registration of the prior image in addition to the reconstruction of projection data. We demonstrate that the combined prior-image- and model-based technique outperforms methods that ignore the prior data or lack a noise model. Moreover, we demonstrate the importance of registration for prior-image-based reconstruction methods and show that the prior-image-registered penalized-likelihood estimation (PIRPLE) approach can maintain a high level of image quality in the presence of noisy and undersampled projection data.

Original languageEnglish (US)
Pages (from-to)7563-7582
Number of pages20
JournalPhysics in medicine and biology
Issue number21
StatePublished - Nov 7 2013

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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