TY - JOUR
T1 - Pindolol in the treatment of hypertension
T2 - Systolic time intervals as a predictor of response to beta receptor blockade
AU - Plotnick, Gary D.
AU - Fisher, Michael L.
AU - Hamilton, Jennifer H.
AU - Robinson, Michael
AU - Carliner, Nathan H.
AU - Janowski, Alphonso H.
AU - Hamilton, Bruce P.
N1 - Funding Information:
From the Department of Medicine, Cardiology and Endocrinology Sections, Veterans Administration Medical Center, University of Maryland School of Medicine, Baltimore, Maryland. This work was supported by a grant from the Veterans Administration, Baltimore, Maryland. Manuscript received August 18, 1979; revised manuscript received October 30, 1979, accepted October 31, 1979.
PY - 1980/3
Y1 - 1980/3
N2 - Seventy-two hypertensive patients were treated with pindolol, a beta adrenergic blocking drug with intrinsic sympathomimetic activity. Serial measurements of systolic time intervals were utilized (1) to determine whether the therapeutic response to pindolol was predictable from pretreatment measurements, and (2) to assess changes in cardiac function during a 15 week treatment period. Patients with an abnormal pretreatment ratio of preejection period to left ventricular ejection time (PEP/LVET) of greater than 0.42 were less likely to respond with a decrease in mean blood pressure of greater than 10 percent (8 of 22) than were patients with a normal (0.42 or less) pretreatment PEP/LVET ratio (33 of 50) (p <0.05). Patients with low renin hypertension were as likely to respond as patients with normal renin hypertension. All three patients with high renin hypertension responded to pindolol. When patients with high renin hypertension were excluded, the systolic time intervals were a better predictor of response than was the renin classification. In patients with an abnormal pretreatment PEP/LVET ratio who responded to pindolol, treatment resulted in an apparent improvement in cardiac function (that is, decrease in PEP/LVET ratio), presumably reflecting the influence of a reduced afterload.
AB - Seventy-two hypertensive patients were treated with pindolol, a beta adrenergic blocking drug with intrinsic sympathomimetic activity. Serial measurements of systolic time intervals were utilized (1) to determine whether the therapeutic response to pindolol was predictable from pretreatment measurements, and (2) to assess changes in cardiac function during a 15 week treatment period. Patients with an abnormal pretreatment ratio of preejection period to left ventricular ejection time (PEP/LVET) of greater than 0.42 were less likely to respond with a decrease in mean blood pressure of greater than 10 percent (8 of 22) than were patients with a normal (0.42 or less) pretreatment PEP/LVET ratio (33 of 50) (p <0.05). Patients with low renin hypertension were as likely to respond as patients with normal renin hypertension. All three patients with high renin hypertension responded to pindolol. When patients with high renin hypertension were excluded, the systolic time intervals were a better predictor of response than was the renin classification. In patients with an abnormal pretreatment PEP/LVET ratio who responded to pindolol, treatment resulted in an apparent improvement in cardiac function (that is, decrease in PEP/LVET ratio), presumably reflecting the influence of a reduced afterload.
UR - http://www.scopus.com/inward/record.url?scp=0018872492&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018872492&partnerID=8YFLogxK
U2 - 10.1016/S0002-9149(80)80013-0
DO - 10.1016/S0002-9149(80)80013-0
M3 - Article
C2 - 6243851
AN - SCOPUS:0018872492
SN - 0002-9149
VL - 45
SP - 614
EP - 620
JO - The American journal of cardiology
JF - The American journal of cardiology
IS - 3
ER -