Pilot trial of albuterol in Duchenne and Becker muscular dystrophy

E. G. Fowler; M. C. Graves; G. T. Wetzel; Melissa J. Spencer

doi:10.1212/01.WNL.0000118530.71646.0F

Pilot trial of albuterol in Duchenne and Becker muscular dystrophy

E. G. Fowler, M. C. Graves, G. T. Wetzel, Melissa J. Spencer

Research output: Contribution to journal › Article › peer-review

Abstract

The authors conducted a randomized, crossover, double-blind, placebo-controlled pilot study of albuterol in nine boys with dystrophinopathies. Primary outcomes were 1) isometric knee extensor and flexor strength; and 2) manual muscle testing (MMT). Isometric knee extensor strength and MMT scores were significantly higher in patients taking albuterol vs placebo. Therefore, 12-week treatment with extended-release albuterol may increase strength in patients with dystrophinopathies. A larger, double-blind, randomized study is necessary to confirm these results.

Original language	English (US)
Pages (from-to)	1006-1008
Number of pages	3
Journal	Neurology
Volume	62
Issue number	6
DOIs	https://doi.org/10.1212/01.WNL.0000118530.71646.0F
State	Published - Mar 23 2004
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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AU - Spencer, Melissa J.

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N2 - The authors conducted a randomized, crossover, double-blind, placebo-controlled pilot study of albuterol in nine boys with dystrophinopathies. Primary outcomes were 1) isometric knee extensor and flexor strength; and 2) manual muscle testing (MMT). Isometric knee extensor strength and MMT scores were significantly higher in patients taking albuterol vs placebo. Therefore, 12-week treatment with extended-release albuterol may increase strength in patients with dystrophinopathies. A larger, double-blind, randomized study is necessary to confirm these results.

AB - The authors conducted a randomized, crossover, double-blind, placebo-controlled pilot study of albuterol in nine boys with dystrophinopathies. Primary outcomes were 1) isometric knee extensor and flexor strength; and 2) manual muscle testing (MMT). Isometric knee extensor strength and MMT scores were significantly higher in patients taking albuterol vs placebo. Therefore, 12-week treatment with extended-release albuterol may increase strength in patients with dystrophinopathies. A larger, double-blind, randomized study is necessary to confirm these results.

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Pilot trial of albuterol in Duchenne and Becker muscular dystrophy

Abstract

ASJC Scopus subject areas

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