Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism

Hyeong Kyu Park; Rexford S. Ahima

doi:10.1016/j.metabol.2014.08.004

Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism

Hyeong Kyu Park, Rexford S. Ahima

Research output: Contribution to journal › Review article › peer-review

292 Scopus citations

Abstract

Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine function, metabolism, immune function and other systems through its effects on the central nervous system and peripheral tissues. Leptin administration has been shown to restore metabolic and neuroendocrine abnormalities in individuals with leptin-deficient states, including hypothalamic amenorrhea and lipoatrophy. In contrast, obese individuals are resistant to leptin. Recombinant leptin is beneficial in patients with congenital leptin deficiency or generalized lipodystrophy. However, further research on molecular mediators of leptin resistance is needed for the development of targeted leptin sensitizing therapies for obesity and related metabolic diseases.

Original language	English (US)
Pages (from-to)	24-34
Number of pages	11
Journal	Metabolism: clinical and experimental
Volume	64
Issue number	1
DOIs	https://doi.org/10.1016/j.metabol.2014.08.004
State	Published - Jan 1 2015
Externally published	Yes

Keywords

Energy homeostasis
Hypothalamus
Leptin
Metabolism
Obesity

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.metabol.2014.08.004

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abstract = "Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine function, metabolism, immune function and other systems through its effects on the central nervous system and peripheral tissues. Leptin administration has been shown to restore metabolic and neuroendocrine abnormalities in individuals with leptin-deficient states, including hypothalamic amenorrhea and lipoatrophy. In contrast, obese individuals are resistant to leptin. Recombinant leptin is beneficial in patients with congenital leptin deficiency or generalized lipodystrophy. However, further research on molecular mediators of leptin resistance is needed for the development of targeted leptin sensitizing therapies for obesity and related metabolic diseases.",

keywords = "Energy homeostasis, Hypothalamus, Leptin, Metabolism, Obesity",

author = "Park, {Hyeong Kyu} and Ahima, {Rexford S.}",

note = "Funding Information: R.S.A is supported by National Institutes of Health grants P01-DK049210 and P30-DK19525 . Publisher Copyright: Copyright {\textcopyright} 2015 Elsevier Inc. All rights reserved.",

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AU - Ahima, Rexford S.

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AB - Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine function, metabolism, immune function and other systems through its effects on the central nervous system and peripheral tissues. Leptin administration has been shown to restore metabolic and neuroendocrine abnormalities in individuals with leptin-deficient states, including hypothalamic amenorrhea and lipoatrophy. In contrast, obese individuals are resistant to leptin. Recombinant leptin is beneficial in patients with congenital leptin deficiency or generalized lipodystrophy. However, further research on molecular mediators of leptin resistance is needed for the development of targeted leptin sensitizing therapies for obesity and related metabolic diseases.

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KW - Hypothalamus

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KW - Obesity

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Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism

Abstract

Keywords

ASJC Scopus subject areas

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