Physical and chemical profiles of nanoparticles for lymphatic targeting

Xiyu Ke, Gregory P. Howard, Haoyu Tang, Bei Cheng, May Tun Saung, José L. Santos, Hai Quan Mao

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Nanoparticles (NPs) have been gaining prominence as delivery vehicles for modulating immune responses to improve treatments against cancer and autoimmune diseases, enhancing tissue regeneration capacity, and potentiating vaccination efficacy. Various engineering approaches have been extensively explored to control the NP physical and chemical properties including particle size, shape, surface charge, hydrophobicity, rigidity and surface targeting ligands to modulate immune responses. This review examines a specific set of physical and chemical characteristics of NPs that enable efficient delivery targeted to secondary lymphoid tissues, specifically the lymph nodes and immune cells. A critical analysis of the structure-property-function relationship will facilitate further efforts to engineer new NPs with unique functionalities, identify novel utilities, and improve the clinical translation of NP formulations for immunotherapy.

Original languageEnglish (US)
Pages (from-to)72-93
Number of pages22
JournalAdvanced Drug Delivery Reviews
StatePublished - Nov 1 2019


  • Immune cells
  • Immunotherapy
  • Lymph node
  • Nanoparticles
  • Physicochemical properties
  • Vaccine

ASJC Scopus subject areas

  • Pharmaceutical Science


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