Physical and chemical profiles of nanoparticles for lymphatic targeting

Xiyu Ke; Gregory P. Howard; Haoyu Tang; Bei Cheng; May Tun Saung; José L. Santos; Hai Quan Mao

doi:10.1016/j.addr.2019.09.005

Physical and chemical profiles of nanoparticles for lymphatic targeting

Xiyu Ke, Gregory P. Howard, Haoyu Tang, Bei Cheng, May Tun Saung, José L. Santos, Hai Quan Mao

School of Medicine

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Nanoparticles (NPs) have been gaining prominence as delivery vehicles for modulating immune responses to improve treatments against cancer and autoimmune diseases, enhancing tissue regeneration capacity, and potentiating vaccination efficacy. Various engineering approaches have been extensively explored to control the NP physical and chemical properties including particle size, shape, surface charge, hydrophobicity, rigidity and surface targeting ligands to modulate immune responses. This review examines a specific set of physical and chemical characteristics of NPs that enable efficient delivery targeted to secondary lymphoid tissues, specifically the lymph nodes and immune cells. A critical analysis of the structure-property-function relationship will facilitate further efforts to engineer new NPs with unique functionalities, identify novel utilities, and improve the clinical translation of NP formulations for immunotherapy.

Original language	English (US)
Pages (from-to)	72-93
Number of pages	22
Journal	Advanced Drug Delivery Reviews
Volume	151-152
DOIs	https://doi.org/10.1016/j.addr.2019.09.005
State	Published - Nov 1 2019

Keywords

Immune cells
Immunotherapy
Lymph node
Nanoparticles
Physicochemical properties
Vaccine

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/j.addr.2019.09.005

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title = "Physical and chemical profiles of nanoparticles for lymphatic targeting",

abstract = "Nanoparticles (NPs) have been gaining prominence as delivery vehicles for modulating immune responses to improve treatments against cancer and autoimmune diseases, enhancing tissue regeneration capacity, and potentiating vaccination efficacy. Various engineering approaches have been extensively explored to control the NP physical and chemical properties including particle size, shape, surface charge, hydrophobicity, rigidity and surface targeting ligands to modulate immune responses. This review examines a specific set of physical and chemical characteristics of NPs that enable efficient delivery targeted to secondary lymphoid tissues, specifically the lymph nodes and immune cells. A critical analysis of the structure-property-function relationship will facilitate further efforts to engineer new NPs with unique functionalities, identify novel utilities, and improve the clinical translation of NP formulations for immunotherapy.",

keywords = "Immune cells, Immunotherapy, Lymph node, Nanoparticles, Physicochemical properties, Vaccine",

author = "Xiyu Ke and Howard, {Gregory P.} and Haoyu Tang and Bei Cheng and Saung, {May Tun} and Santos, {Jos{\'e} L.} and Mao, {Hai Quan}",

note = "Funding Information: This work was supported by the National Institutes of Health (R21 5R21AI133533), the National Science Foundation (GRFP DGE1746891), and a AstraZeneca MedImmune Partnership Grant. Funding Information: This work was supported by the National Institutes of Health ( R21 5R21AI133533 ), the National Science Foundation ( GRFP DGE1746891 ), and a AstraZeneca MedImmune Partnership Grant . Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

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doi = "10.1016/j.addr.2019.09.005",

language = "English (US)",

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AU - Ke, Xiyu

AU - Howard, Gregory P.

AU - Tang, Haoyu

AU - Cheng, Bei

AU - Saung, May Tun

AU - Santos, José L.

AU - Mao, Hai Quan

N1 - Funding Information: This work was supported by the National Institutes of Health (R21 5R21AI133533), the National Science Foundation (GRFP DGE1746891), and a AstraZeneca MedImmune Partnership Grant. Funding Information: This work was supported by the National Institutes of Health ( R21 5R21AI133533 ), the National Science Foundation ( GRFP DGE1746891 ), and a AstraZeneca MedImmune Partnership Grant . Publisher Copyright: © 2019 Elsevier B.V.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Nanoparticles (NPs) have been gaining prominence as delivery vehicles for modulating immune responses to improve treatments against cancer and autoimmune diseases, enhancing tissue regeneration capacity, and potentiating vaccination efficacy. Various engineering approaches have been extensively explored to control the NP physical and chemical properties including particle size, shape, surface charge, hydrophobicity, rigidity and surface targeting ligands to modulate immune responses. This review examines a specific set of physical and chemical characteristics of NPs that enable efficient delivery targeted to secondary lymphoid tissues, specifically the lymph nodes and immune cells. A critical analysis of the structure-property-function relationship will facilitate further efforts to engineer new NPs with unique functionalities, identify novel utilities, and improve the clinical translation of NP formulations for immunotherapy.

AB - Nanoparticles (NPs) have been gaining prominence as delivery vehicles for modulating immune responses to improve treatments against cancer and autoimmune diseases, enhancing tissue regeneration capacity, and potentiating vaccination efficacy. Various engineering approaches have been extensively explored to control the NP physical and chemical properties including particle size, shape, surface charge, hydrophobicity, rigidity and surface targeting ligands to modulate immune responses. This review examines a specific set of physical and chemical characteristics of NPs that enable efficient delivery targeted to secondary lymphoid tissues, specifically the lymph nodes and immune cells. A critical analysis of the structure-property-function relationship will facilitate further efforts to engineer new NPs with unique functionalities, identify novel utilities, and improve the clinical translation of NP formulations for immunotherapy.

KW - Immune cells

KW - Immunotherapy

KW - Lymph node

KW - Nanoparticles

KW - Physicochemical properties

KW - Vaccine

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ER -

Physical and chemical profiles of nanoparticles for lymphatic targeting

Abstract

Keywords

ASJC Scopus subject areas

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