TY - GEN
T1 - Photothermal imaging through coherent infrared bundles
AU - Milstein, Yonat
AU - Tepper, Michal
AU - Harrington, James A.
AU - Ben David, Moshe
AU - Gannot, Israel
PY - 2011/4/21
Y1 - 2011/4/21
N2 - This study aims to develop a photothermal imaging system through a coherent infrared bundle. This system will be used to determine the oxygenation level of various tissues, suspected malignant tissues in particular. The oxygenation estimation is preformed using a computerized algorithm. In order to evaluate the system, different bundle configurations were used for the determination of the optimal one. Bundle transmittance and the algorithm's estimation ability were measured, measurements were performed using agar phantoms consisting of varying ratios of Methylene Blue and ICG. A bundle consisting of 19 Teflon waveguides with a of 1.1mm was found to be the optimal configuration with an RMS of the error of 9.38%. At a second stage the system was validated on blood samples with varying oxygenation levels and there oxygenation levels were estimated. This stage had an RMS of the error of 10.16% for the oxygenation level estimation for samples with a 50% oxygenation level and higher. Once the basic system was validated successfully on agar phantoms and blood samples a portable system was designed and built in order to fit the system for portable use. The portable system consists of a white light illuminating source followed by filters transmitting certain wavelengths, a transmitting fiber, a thermal imaging bundle and a portable thermal camera. This portable system will be evaluated in order to have an adequate portable system for implementing the method out of the lab.
AB - This study aims to develop a photothermal imaging system through a coherent infrared bundle. This system will be used to determine the oxygenation level of various tissues, suspected malignant tissues in particular. The oxygenation estimation is preformed using a computerized algorithm. In order to evaluate the system, different bundle configurations were used for the determination of the optimal one. Bundle transmittance and the algorithm's estimation ability were measured, measurements were performed using agar phantoms consisting of varying ratios of Methylene Blue and ICG. A bundle consisting of 19 Teflon waveguides with a of 1.1mm was found to be the optimal configuration with an RMS of the error of 9.38%. At a second stage the system was validated on blood samples with varying oxygenation levels and there oxygenation levels were estimated. This stage had an RMS of the error of 10.16% for the oxygenation level estimation for samples with a 50% oxygenation level and higher. Once the basic system was validated successfully on agar phantoms and blood samples a portable system was designed and built in order to fit the system for portable use. The portable system consists of a white light illuminating source followed by filters transmitting certain wavelengths, a transmitting fiber, a thermal imaging bundle and a portable thermal camera. This portable system will be evaluated in order to have an adequate portable system for implementing the method out of the lab.
KW - coherent waveguide bundle
KW - photothermal spectroscopy
KW - thermal imaging
KW - thermal imaging bundle
KW - tissue oxygenation
UR - http://www.scopus.com/inward/record.url?scp=79954553705&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79954553705&partnerID=8YFLogxK
U2 - 10.1117/12.882006
DO - 10.1117/12.882006
M3 - Conference contribution
AN - SCOPUS:79954553705
SN - 9780819484314
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Optical Fibers, Sensors, and Devices for Biomedical Diagnostics and Treatment XI
T2 - Optical Fibers, Sensors, and Devices for Biomedical Diagnostics and Treatment XI
Y2 - 22 January 2011 through 23 January 2011
ER -