Photopigment bleaching phenomenon with scanning laser ophthalmoscopy and fluorescein angiography

Mark P. Breazzano, Pedro Fernandez-Avellaneda, Shree K. Kurup, K. Bailey Freund

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Photopigment bleaching occurs with saturation of photoreceptor pigment by shortwavelength fundus autofluorescence imaging. This phenomenon is seen as characteristic hyperautofluorescence with subsequent imaging acquisition. Herein, a patient with multiple sclerosis was found to exhibit increased choroidal hyperfluorescence during fluorescein angiography (FA) that corresponded with a circumscribed area of intense blue light exposure during initial scanning laser ophthalmoscopy. To the authors' knowledge, this case is the first description of photobleaching phenomenon during FA and should be recognized as nonpathologic by the clinician.

Original languageEnglish (US)
Pages (from-to)590-592
Number of pages3
JournalOphthalmic Surgery Lasers and Imaging Retina
Issue number9
StatePublished - 2019
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology


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