Photonic approach to the selective inactivation of viruses with a near-infrared ultrashort pulsed laser

K. T. Tsen; Shaw Wei D. Tsen; Q. Fu; S. M. Lindsay; K. Kibler; B. Jacobs; T. C. Wu; Zhe Li; Hao Yan; Stephanie Cope; Sara Vaiana; Juliann G. Kiang

doi:10.1117/12.841316

Photonic approach to the selective inactivation of viruses with a near-infrared ultrashort pulsed laser

K. T. Tsen, Shaw Wei D. Tsen, Q. Fu, S. M. Lindsay, K. Kibler, B. Jacobs, T. C. Wu, Zhe Li, Hao Yan, Stephanie Cope, Sara Vaiana, Juliann G. Kiang

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

We report a photonic approach for selective inactivation of viruses with a near-infrared ultrashort pulsed (USP) laser. We demonstrate that this method can selectively inactivate viral particles ranging from nonpathogenic viruses such as M13 bacteriophage, tobacco mosaic virus (TMV) to pathogenic viruses like human papillomavirus (HPV) and human immunodeficiency virus (HIV). At the same time sensitive materials like human Jurkat T cells, human red blood cells, and mouse dendritic cells remain unharmed. Our photonic approach could be used for the disinfection of viral pathogens in blood products and for the treatment of blood-borne viral diseases in the clinic.

Original language	English (US)
Title of host publication	Optical Biopsy VII
DOIs	https://doi.org/10.1117/12.841316
State	Published - 2010
Event	Optical Biopsy VII - San Francisco, CA, United States Duration: Jan 25 2010 → Jan 28 2010

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	7561
ISSN (Print)	1605-7422

Other

Other	Optical Biopsy VII
Country/Territory	United States
City	San Francisco, CA
Period	1/25/10 → 1/28/10

Keywords

Femtosecond lasers
Inactivation of viruses
Photonics

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging
Biomaterials

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10.1117/12.841316

Cite this

Tsen, K. T., Tsen, S. W. D., Fu, Q., Lindsay, S. M., Kibler, K., Jacobs, B., Wu, T. C., Li, Z., Yan, H., Cope, S., Vaiana, S., & Kiang, J. G. (2010). Photonic approach to the selective inactivation of viruses with a near-infrared ultrashort pulsed laser. In Optical Biopsy VII Article 75610W (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7561). https://doi.org/10.1117/12.841316

Tsen, KT, Tsen, SWD, Fu, Q, Lindsay, SM, Kibler, K, Jacobs, B, Wu, TC, Li, Z, Yan, H, Cope, S, Vaiana, S & Kiang, JG 2010, Photonic approach to the selective inactivation of viruses with a near-infrared ultrashort pulsed laser. in Optical Biopsy VII., 75610W, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 7561, Optical Biopsy VII, San Francisco, CA, United States, 1/25/10. https://doi.org/10.1117/12.841316

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title = "Photonic approach to the selective inactivation of viruses with a near-infrared ultrashort pulsed laser",

abstract = "We report a photonic approach for selective inactivation of viruses with a near-infrared ultrashort pulsed (USP) laser. We demonstrate that this method can selectively inactivate viral particles ranging from nonpathogenic viruses such as M13 bacteriophage, tobacco mosaic virus (TMV) to pathogenic viruses like human papillomavirus (HPV) and human immunodeficiency virus (HIV). At the same time sensitive materials like human Jurkat T cells, human red blood cells, and mouse dendritic cells remain unharmed. Our photonic approach could be used for the disinfection of viral pathogens in blood products and for the treatment of blood-borne viral diseases in the clinic.",

keywords = "Femtosecond lasers, Inactivation of viruses, Photonics",

author = "Tsen, {K. T.} and Tsen, {Shaw Wei D.} and Q. Fu and Lindsay, {S. M.} and K. Kibler and B. Jacobs and Wu, {T. C.} and Zhe Li and Hao Yan and Stephanie Cope and Sara Vaiana and Kiang, {Juliann G.}",

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doi = "10.1117/12.841316",

language = "English (US)",

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series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

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note = "Optical Biopsy VII ; Conference date: 25-01-2010 Through 28-01-2010",

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T1 - Photonic approach to the selective inactivation of viruses with a near-infrared ultrashort pulsed laser

AU - Tsen, K. T.

AU - Tsen, Shaw Wei D.

AU - Fu, Q.

AU - Lindsay, S. M.

AU - Kibler, K.

AU - Jacobs, B.

AU - Wu, T. C.

AU - Li, Zhe

AU - Yan, Hao

AU - Cope, Stephanie

AU - Vaiana, Sara

AU - Kiang, Juliann G.

PY - 2010

Y1 - 2010

N2 - We report a photonic approach for selective inactivation of viruses with a near-infrared ultrashort pulsed (USP) laser. We demonstrate that this method can selectively inactivate viral particles ranging from nonpathogenic viruses such as M13 bacteriophage, tobacco mosaic virus (TMV) to pathogenic viruses like human papillomavirus (HPV) and human immunodeficiency virus (HIV). At the same time sensitive materials like human Jurkat T cells, human red blood cells, and mouse dendritic cells remain unharmed. Our photonic approach could be used for the disinfection of viral pathogens in blood products and for the treatment of blood-borne viral diseases in the clinic.

AB - We report a photonic approach for selective inactivation of viruses with a near-infrared ultrashort pulsed (USP) laser. We demonstrate that this method can selectively inactivate viral particles ranging from nonpathogenic viruses such as M13 bacteriophage, tobacco mosaic virus (TMV) to pathogenic viruses like human papillomavirus (HPV) and human immunodeficiency virus (HIV). At the same time sensitive materials like human Jurkat T cells, human red blood cells, and mouse dendritic cells remain unharmed. Our photonic approach could be used for the disinfection of viral pathogens in blood products and for the treatment of blood-borne viral diseases in the clinic.

KW - Femtosecond lasers

KW - Inactivation of viruses

KW - Photonics

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M3 - Conference contribution

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SN - 9780819479570

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Optical Biopsy VII

T2 - Optical Biopsy VII

Y2 - 25 January 2010 through 28 January 2010

ER -

Photonic approach to the selective inactivation of viruses with a near-infrared ultrashort pulsed laser

Abstract

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Keywords

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