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Photoacoustic tomography with novel optical contrast agents based on gold nanocages or nanoparticles containing near-infrared dyes

  • Xinmai Yang
  • , Sara Skrabalak
  • , Erich Stein
  • , Bin Wu
  • , Xunbin Wei
  • , Younan Xia
  • , Lihong V. Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Poly(ethylene glycol)-coated Au nanocages have been evaluated as a potential near-infrared (NIR) contrast agent for photoacoustic tomography (PAT). Previously, Au nanoshells were found to be an effective NIR contrast agent for PAT; however, Au nanocages, with their more compact sizes (<50 nm compared to >100 nm for Au nanoshells) and larger optical absorption cross-sections, should be better suited for in vivo applications. In this study, we tested Au nanocages as a contrast agent for PAT. The result suggests that Au nanocages are promising contrast agents for our applications. We also present PAT results when novel, dye-containing nanoparticles are used as contrast agents.

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
PublisherSPIE
ISBN (Print)9780819470317
DOIs
StatePublished - Feb 28 2008
Externally publishedYes
Event9th Conference on Photons Plus Ultrasound: Imaging and Sensing 2008 - San Jose, CA, United States
Duration: Jan 20 2008Jan 23 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6856
ISSN (Print)1605-7422

Conference

Conference9th Conference on Photons Plus Ultrasound: Imaging and Sensing 2008
Country/TerritoryUnited States
CitySan Jose, CA
Period1/20/081/23/08

Keywords

  • Dye-containing nanoparticles
  • Image reconstruction
  • Nanocages
  • Photoacoustic tomography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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