Photoacoustic imaging of prostate brachytherapy seeds in Ex vivo prostate

Nathanael Kuo, Hyun Jae Kang, Travis Dejournett, James Spicer, Emad Boctor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Scopus citations


The localization of brachytherapy seeds in relation to the prostate is a key step in intraoperative treatment planning (ITP) for improving outcomes in prostate cancer patients treated with low dose rate prostate brachytherapy. Transrectal ultrasound (TRUS) has traditionally been the modality of choice to guide the prostate brachytherapy procedure due to its relatively low cost and apparent ease of use. However, TRUS is unable to visualize seeds well, precluding ITP and producing suboptimal results. While other modalities such as X-ray and magnetic resonance imaging have been investigated to localize seeds in relation to the prostate, photoacoustic imaging has become an emerging and promising modality to solve this challenge. Moreover, photoacoustic imaging may be more practical in the clinical setting compared to other methods since it adds little additional equipment to the ultrasound system already adopted in procedure today, reducing cost and simplifying engineering steps. In this paper, we demonstrate the latest efforts of localizing prostate brachytherapy seeds using photoacoustic imaging, including visualization of multiple seeds in actual prostate tissue. Although there are still several challenges to be met before photoacoustic imaging can be used in the operating room, we are pleased to present the current progress in this effort.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2011
Subtitle of host publicationVisualization, Image-Guided Procedures, and Modeling
StatePublished - May 16 2011
EventMedical Imaging 2011: Visualization, Image-Guided Procedures, and Modeling - Lake Buena Vista, FL, United States
Duration: Feb 13 2011Feb 15 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2011: Visualization, Image-Guided Procedures, and Modeling
Country/TerritoryUnited States
CityLake Buena Vista, FL


  • Photoacoustic imaging
  • Prostate brachytherapy
  • Seed localization

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Photoacoustic imaging of prostate brachytherapy seeds in Ex vivo prostate'. Together they form a unique fingerprint.

Cite this