Phosphodiesterases and cyclic GMP regulation in heart muscle

Dong I. Lee; David A. Kass

doi:10.1152/physiol.00011.2012

Phosphodiesterases and cyclic GMP regulation in heart muscle

Dong I. Lee, David A. Kass

School of Medicine

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

The cyclic nucleotide cGMP and its corresponding activated kinase cGK-1 serve as a counterbalance to acute and chronic myocardial stress. cGMP hydrolysis by several members of the phosphodiesterase (PDE) superfamily, PDE1, PDE2, and PDE5, regulate this signaling in the heart. This review details new insights regarding how these PDEs modulate cGMP and cGK-1 to influence heart function and chronic stress responses, and how their inhibition may provide potential therapeutic benefits.

Original language	English (US)
Pages (from-to)	248-258
Number of pages	11
Journal	Physiology
Volume	27
Issue number	4
DOIs	https://doi.org/10.1152/physiol.00011.2012
State	Published - Aug 1 2012

ASJC Scopus subject areas

Physiology

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AB - The cyclic nucleotide cGMP and its corresponding activated kinase cGK-1 serve as a counterbalance to acute and chronic myocardial stress. cGMP hydrolysis by several members of the phosphodiesterase (PDE) superfamily, PDE1, PDE2, and PDE5, regulate this signaling in the heart. This review details new insights regarding how these PDEs modulate cGMP and cGK-1 to influence heart function and chronic stress responses, and how their inhibition may provide potential therapeutic benefits.

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Phosphodiesterases and cyclic GMP regulation in heart muscle

Abstract

ASJC Scopus subject areas

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