Phospho-ΔNp63α-responsive microRNAs contribute to the regulation of necroptosis in squamous cell carcinoma upon cisplatin exposure

Edward A. Ratovitski

doi:10.1016/j.febslet.2015.04.020

Phospho-ΔNp63α-responsive microRNAs contribute to the regulation of necroptosis in squamous cell carcinoma upon cisplatin exposure

Edward A. Ratovitski

School of Medicine

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Abstract This study shows that specific microRNAs differentially regulated by ΔNp63α in cisplatin-sensitive and resistant squamous cell carcinoma (SSC) cells of larynx and tongue affect the expression of members of the necroptotic pathway CYLD, RIPK1, and MLKL. Different degrees of protein interaction between necroptotic signaling intermediates were also observed in SCC cells sensitive or resistant to cisplatin. Modulation of RIPK1 with miR-101-3p mimic or inhibitor, as well as with siRNA, or chemical inhibitors was shown to affect sensitivity of SCC cells to cisplatin. This is the first report showing the modulatory effect of ΔNp63α-responsive microRNAs on the specific members of necroptotic pathway in SCC tumor cells variably responding to platinum chemotherapy.

Original language	English (US)
Article number	37115
Pages (from-to)	1352-1358
Number of pages	7
Journal	FEBS Letters
Volume	589
Issue number	12
DOIs	https://doi.org/10.1016/j.febslet.2015.04.020
State	Published - May 22 2015

Keywords

Cancer
Chemoresistance
Cisplatin
microRNA
Necroptosis
Tumor protein p63

ASJC Scopus subject areas

Biochemistry
Biophysics
Cell Biology
Genetics
Molecular Biology
Structural Biology
General Medicine

Access to Document

10.1016/j.febslet.2015.04.020

Cite this

@article{9af41cf84aa74457b4fb1047f19b9228,

title = "Phospho-ΔNp63α-responsive microRNAs contribute to the regulation of necroptosis in squamous cell carcinoma upon cisplatin exposure",

abstract = "Abstract This study shows that specific microRNAs differentially regulated by ΔNp63α in cisplatin-sensitive and resistant squamous cell carcinoma (SSC) cells of larynx and tongue affect the expression of members of the necroptotic pathway CYLD, RIPK1, and MLKL. Different degrees of protein interaction between necroptotic signaling intermediates were also observed in SCC cells sensitive or resistant to cisplatin. Modulation of RIPK1 with miR-101-3p mimic or inhibitor, as well as with siRNA, or chemical inhibitors was shown to affect sensitivity of SCC cells to cisplatin. This is the first report showing the modulatory effect of ΔNp63α-responsive microRNAs on the specific members of necroptotic pathway in SCC tumor cells variably responding to platinum chemotherapy.",

keywords = "Cancer, Chemoresistance, Cisplatin, microRNA, Necroptosis, Tumor protein p63",

author = "Ratovitski, {Edward A.}",

year = "2015",

month = may,

day = "22",

doi = "10.1016/j.febslet.2015.04.020",

language = "English (US)",

volume = "589",

pages = "1352--1358",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Elsevier",

number = "12",

}

TY - JOUR

T1 - Phospho-ΔNp63α-responsive microRNAs contribute to the regulation of necroptosis in squamous cell carcinoma upon cisplatin exposure

AU - Ratovitski, Edward A.

PY - 2015/5/22

Y1 - 2015/5/22

N2 - Abstract This study shows that specific microRNAs differentially regulated by ΔNp63α in cisplatin-sensitive and resistant squamous cell carcinoma (SSC) cells of larynx and tongue affect the expression of members of the necroptotic pathway CYLD, RIPK1, and MLKL. Different degrees of protein interaction between necroptotic signaling intermediates were also observed in SCC cells sensitive or resistant to cisplatin. Modulation of RIPK1 with miR-101-3p mimic or inhibitor, as well as with siRNA, or chemical inhibitors was shown to affect sensitivity of SCC cells to cisplatin. This is the first report showing the modulatory effect of ΔNp63α-responsive microRNAs on the specific members of necroptotic pathway in SCC tumor cells variably responding to platinum chemotherapy.

AB - Abstract This study shows that specific microRNAs differentially regulated by ΔNp63α in cisplatin-sensitive and resistant squamous cell carcinoma (SSC) cells of larynx and tongue affect the expression of members of the necroptotic pathway CYLD, RIPK1, and MLKL. Different degrees of protein interaction between necroptotic signaling intermediates were also observed in SCC cells sensitive or resistant to cisplatin. Modulation of RIPK1 with miR-101-3p mimic or inhibitor, as well as with siRNA, or chemical inhibitors was shown to affect sensitivity of SCC cells to cisplatin. This is the first report showing the modulatory effect of ΔNp63α-responsive microRNAs on the specific members of necroptotic pathway in SCC tumor cells variably responding to platinum chemotherapy.

KW - Cancer

KW - Chemoresistance

KW - Cisplatin

KW - microRNA

KW - Necroptosis

KW - Tumor protein p63

UR - http://www.scopus.com/inward/record.url?scp=84937763878&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937763878&partnerID=8YFLogxK

U2 - 10.1016/j.febslet.2015.04.020

DO - 10.1016/j.febslet.2015.04.020

M3 - Article

C2 - 25910754

AN - SCOPUS:84937763878

SN - 0014-5793

VL - 589

SP - 1352

EP - 1358

JO - FEBS Letters

JF - FEBS Letters

IS - 12

M1 - 37115

ER -

Phospho-ΔNp63α-responsive microRNAs contribute to the regulation of necroptosis in squamous cell carcinoma upon cisplatin exposure

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this