Phenomenological comparisons of major depression following stroke, myocardial infarction or spinal cord lesions

J. Paul Fedoroff, John R. Lipsey, Sergio E. Starkstein, Alfred Forrester, Thomas R. Price, Robert G. Robinson

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Patients with major depression admitted to hospital with acute stroke (n = 44), acute myocardial infarction (n = 25), or acute spinal cord injury (n = 12) were examined for differences in their phenomenological presentation of major depression. Depressed stroke patients were found to have significantly higher scores on the syndrome clusters for generalized anxiety and ideas of reference than depressed cardiac or spinal cord injury patients. In addition, significantly more stroke patients met diagnostic criteria for generalized anxiety disorder compared with the other two groups. Although spinal cord injury patients were younger, more likely to be treated with benzodiazepines, and less likely to be treated with β-blockers, none of these factors distinguished stroke patients with anxious depression from stroke patients with depression only. These findings are consistent with the hypothesis that the etiology of depression following stroke may be different from that associated with myocardial infarction or spinal cord injury.

Original languageEnglish (US)
Pages (from-to)83-89
Number of pages7
JournalJournal of Affective Disorders
Issue number1-2
StatePublished - 1991


  • Myocardial infarction
  • Spinal cord lesions
  • Stroke

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health


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