Phase-sensitive inversion recovery for detecting myocardial infarction using gadolinium-delayed hyperenhancement

Peter Kellman, Andrew E. Arai, Elliot R. McVeigh, Anthony H. Aletras

Research output: Contribution to journalArticlepeer-review

424 Scopus citations


After administration of gadolinium, infarcted myocardium exhibits delayed hyperenhancement and can be imaged using an inversion recovery (IR) sequence. The performance of such a method when using magnitude-reconstructed images is highly sensitive to the inversion recovery time (TI) selected. Using phase-sensitive reconstruction, it is possible to use a nominal value of TI, eliminate several breath-holds otherwise needed to find the precise null time for normal myocardium, and achieve a consistent contrast. Phase-sensitive detection is used to remove the background phase while preserving the sign of the desired magnetization during IR. Experimental results are presented which demonstrate the benefits of both phase-sensitive IR image reconstruction and surface coil intensity normalization for detecting myocardial infarction (MI). The phase-sensitive reconstruction method reduces the variation in apparent infarct size that is observed in the magnitude images as TI is changed. Phase-sensitive detection also has the advantage of decreasing the sensitivity to changes in tissue T1 with increasing delay from contrast agent injection.

Original languageEnglish (US)
Pages (from-to)372-383
Number of pages12
JournalMagnetic Resonance in Medicine
Issue number2
StatePublished - 2002
Externally publishedYes


  • Cardiac imaging
  • Delayed hyperenhancement
  • Intensity correction
  • Inversion recovery
  • Myocardial infarction
  • Phase-sensitive reconstruction

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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