Phase II trial of docetaxel-irinotecan combination in advanced esophageal cancer

Barbara Burtness, M. Gibson, B. Egleston, R. Mehra, L. Thomas, R. Sipples, M. Quintanilla, J. Lacy, S. Watkins, J. R. Murren, A. A. Forastiere

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Background: Preclinical evidence suggests synergy between docetaxel and irinotecan, two drugs active in esophagogastric cancer. We previously demonstrated the safety of docetaxel 35 mg/m2 and irinotecan 50 mg/m2 given on days 1 and 8 of a 21-day schedule. Materials and methods: Patients who had unresectable/metastatic squamous cell carcinoma or adenocarcinoma of the esophagus, measurable disease, Eastern Cooperative Oncology Group performance status of zero to two, and normal bilirubin were eligible. Tumor assessment was carried out every three cycles. Results: We enrolled 29 chemotherapy-naive (CN) and 15 chemotherapy-exposed (CE) eligible patients. Principal toxic effects were diarrhea, neutropenia, and hyperglycemia. There were no toxic deaths. There was one early death, from myocardial infarction. Among 26 CN and assessable patients, there were seven (26.9%) with a partial response (PR) and one (3.8%) with a complete response (CR). There were two PRs and one CR among the patients with CE disease. Median time to progression for CN patients was 4.0 months and for CE patients 3.5 months. Median survival for CN eligible patients was 9.0 months and for CE patients 11.4 months. Conclusions: Docetaxel-irinotecan combination given on a weekly × 2 of 3 schedule is promising in the treatment of advanced esophageal cancer.

Original languageEnglish (US)
Pages (from-to)1242-1248
Number of pages7
JournalAnnals of Oncology
Issue number7
StatePublished - 2009


  • Chemotherapy
  • Docetaxel
  • Esophageal cancer
  • Irinotecan

ASJC Scopus subject areas

  • Hematology
  • Oncology


Dive into the research topics of 'Phase II trial of docetaxel-irinotecan combination in advanced esophageal cancer'. Together they form a unique fingerprint.

Cite this