Pharmacotherapy for treatment of complex regional pain syndrome

Emmett E. Whitaker, Michael Erdek

Research output: Contribution to journalReview articlepeer-review


Complex regional pain syndrome (CRPS) is an ill-defined, poorly understood disorder that causes significant morbidity in those who suffer from it. It is estimated that up to 20% to 35% of patients will remain incapacitated indefinitely and that only 20% to 30% of patients will be able to return to their previous full-time employment. A number of treatments, interventional and noninterventional, have been posited as possible therapies for CRPS. We discuss and review here the evidence-based rationale for pharmacologic therapy for CRPS.

Original languageEnglish (US)
Pages (from-to)277-282
Number of pages6
JournalNeurosurgery Quarterly
Issue number4
StatePublished - Dec 2008


  • Anticonvulsant
  • CRPS
  • Calcium channel blocker
  • Clonidine
  • Complex regional pain syndrome
  • DMSO
  • Free radical scavengers
  • Gabapentin
  • Lidocaine patch
  • Memantine
  • NSAIDs
  • Nifedipine
  • Opioids
  • Pregabalin
  • Systemic lidocaine
  • TCA
  • Thalidomide
  • Tricyclic antidepressant

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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