TY - JOUR
T1 - Pharmacotherapy for tobacco dependence
AU - Fant, Reginald V.
AU - Buchhalter, August R.
AU - Buchman, Albert C.
AU - Henningfield, Jack E.
PY - 2009
Y1 - 2009
N2 - Pharmacotherapy can provide effective treatment of tobacco dependence and withdrawal, and thereby facilitate efforts to achieve and sustain tobacco abstinence. Currently approved medications for smoking cessation are nicotine replacement medications (NRT), including nicotine patch, gum, lozenge, sublin-gual tablet, inhaler and nasal spray, the antidepressant bupropion, and the nicotinic partial agonist varenicline. This review discusses the pharmacological basis for the use of these medications, and the properties that might contribute to their efficacy, safety, and abuse liability. The review also discusses how pharmacological principles can be used to improve existing medications, as well as assist in the development of new medications.
AB - Pharmacotherapy can provide effective treatment of tobacco dependence and withdrawal, and thereby facilitate efforts to achieve and sustain tobacco abstinence. Currently approved medications for smoking cessation are nicotine replacement medications (NRT), including nicotine patch, gum, lozenge, sublin-gual tablet, inhaler and nasal spray, the antidepressant bupropion, and the nicotinic partial agonist varenicline. This review discusses the pharmacological basis for the use of these medications, and the properties that might contribute to their efficacy, safety, and abuse liability. The review also discusses how pharmacological principles can be used to improve existing medications, as well as assist in the development of new medications.
UR - http://www.scopus.com/inward/record.url?scp=63849337629&partnerID=8YFLogxK
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U2 - 10.1007/978-3-540-69248-5_17
DO - 10.1007/978-3-540-69248-5_17
M3 - Article
C2 - 19184660
AN - SCOPUS:63849337629
SN - 0171-2004
VL - 192
SP - 487
EP - 510
JO - Handbook of Experimental Pharmacology
JF - Handbook of Experimental Pharmacology
ER -