Pharmacotherapy for Substance Use Disorders in Youths

Christopher J. Hammond, Kevin M. Gray

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Despite recent advances in psychosocial treatments targeting adolescent substance use disorders (SUD), effect sizes generally remain small to modest, and few treatment-enrolled youths achieve sustained abstinence. Among adults, SUD-targeted pharmacotherapies have emerged as viable options to complement psychosocial treatments and enhance outcomes. Developmental differences exist in pharmacodynamics and treatment response, and comparatively little research has focused on SUD-targeted pharmacotherapies for youths. This article provides a review and synthesis of relevant published clinical trials focusing on youth SUDs and co-occurring/comorbid psychiatric and substance use disorders. It offers recommendations for clinical practice and further research based on the limited findings to date.

Original languageEnglish (US)
Pages (from-to)292-316
Number of pages25
JournalJournal of Child and Adolescent Substance Abuse
Issue number4
StatePublished - Jul 3 2016


  • adolescence
  • pharmacotherapy
  • substance use disorders
  • youth

ASJC Scopus subject areas

  • Social Psychology
  • Education
  • Psychology(all)
  • Public Health, Environmental and Occupational Health


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