Pharmacologic activities of copper compounds in chronic diseases

John R.J. Sorenson; Larry W. Oberley; Rosalie K. Crouch; Thomas W. Kensler; Vimal Kishore; Susan W.C. Leuthauser; Terry D. Oberley; Abbas Pezeshk

doi:10.1007/BF02987212

Pharmacologic activities of copper compounds in chronic diseases

John R.J. Sorenson, Larry W. Oberley, Rosalie K. Crouch, Thomas W. Kensler, Vimal Kishore, Susan W.C. Leuthauser, Terry D. Oberley, Abbas Pezeshk

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Copper complexes have been shown to be effective antiinflammatory, antiulcer, anticonvulsant, anticancer, and antidiabetic agents. This seemingly diverse variety of pharmacologic effects is unified by the hypothesis that copper complexes facilitate or promote tissue repair processes involving copper-dependent enzymes and that arthritis, ulcers, seizures, neoplasia, and diabetes are diseases of specific tissues in disrepair. The corollary to this hypothesis is that the loss or reduction of copper-dependent enzyme-mediated processes leads to tissue dysfunction that may be reversed with copper complex therapy.

Original language	English (US)
Pages (from-to)	257-273
Number of pages	17
Journal	Biological Trace Element Research
Volume	5
Issue number	4-5
DOIs	https://doi.org/10.1007/BF02987212
State	Published - Aug 1983

Keywords

Copper complexes, antiinflammatory activity of
anticancer agents, copper complexes as
anticonvulsants, copper complexes as
antidiabetic agents, copper complexes as
antiulcer agents, copper complexes as
copper-dependent enzymes

ASJC Scopus subject areas

Biochemistry, medical
Biochemistry
Clinical Biochemistry
Inorganic Chemistry
Endocrinology, Diabetes and Metabolism

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10.1007/BF02987212

Cite this

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title = "Pharmacologic activities of copper compounds in chronic diseases",

abstract = "Copper complexes have been shown to be effective antiinflammatory, antiulcer, anticonvulsant, anticancer, and antidiabetic agents. This seemingly diverse variety of pharmacologic effects is unified by the hypothesis that copper complexes facilitate or promote tissue repair processes involving copper-dependent enzymes and that arthritis, ulcers, seizures, neoplasia, and diabetes are diseases of specific tissues in disrepair. The corollary to this hypothesis is that the loss or reduction of copper-dependent enzyme-mediated processes leads to tissue dysfunction that may be reversed with copper complex therapy.",

keywords = "Copper complexes, antiinflammatory activity of, anticancer agents, copper complexes as, anticonvulsants, copper complexes as, antidiabetic agents, copper complexes as, antiulcer agents, copper complexes as, copper-dependent enzymes",

author = "Sorenson, {John R.J.} and Oberley, {Larry W.} and Crouch, {Rosalie K.} and Kensler, {Thomas W.} and Vimal Kishore and Leuthauser, {Susan W.C.} and Oberley, {Terry D.} and Abbas Pezeshk",

year = "1983",

month = aug,

doi = "10.1007/BF02987212",

language = "English (US)",

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pages = "257--273",

journal = "Biological Trace Element Research",

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T1 - Pharmacologic activities of copper compounds in chronic diseases

AU - Sorenson, John R.J.

AU - Oberley, Larry W.

AU - Crouch, Rosalie K.

AU - Kensler, Thomas W.

AU - Kishore, Vimal

AU - Leuthauser, Susan W.C.

AU - Oberley, Terry D.

AU - Pezeshk, Abbas

PY - 1983/8

Y1 - 1983/8

N2 - Copper complexes have been shown to be effective antiinflammatory, antiulcer, anticonvulsant, anticancer, and antidiabetic agents. This seemingly diverse variety of pharmacologic effects is unified by the hypothesis that copper complexes facilitate or promote tissue repair processes involving copper-dependent enzymes and that arthritis, ulcers, seizures, neoplasia, and diabetes are diseases of specific tissues in disrepair. The corollary to this hypothesis is that the loss or reduction of copper-dependent enzyme-mediated processes leads to tissue dysfunction that may be reversed with copper complex therapy.

AB - Copper complexes have been shown to be effective antiinflammatory, antiulcer, anticonvulsant, anticancer, and antidiabetic agents. This seemingly diverse variety of pharmacologic effects is unified by the hypothesis that copper complexes facilitate or promote tissue repair processes involving copper-dependent enzymes and that arthritis, ulcers, seizures, neoplasia, and diabetes are diseases of specific tissues in disrepair. The corollary to this hypothesis is that the loss or reduction of copper-dependent enzyme-mediated processes leads to tissue dysfunction that may be reversed with copper complex therapy.

KW - Copper complexes, antiinflammatory activity of

KW - anticancer agents, copper complexes as

KW - anticonvulsants, copper complexes as

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Pharmacologic activities of copper compounds in chronic diseases

Abstract

Keywords

ASJC Scopus subject areas

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