Pharmacokinetics of Polymeric Drug Delivery

Riccardo Serra, Sakibul Huq, Henry Brem, Betty Tyler

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Many aspects of polymeric drug delivery have been investigated over the past three decades, and pharmacokinetic and pharmacodynamic models have been developed to enhance our understanding of properties such as polymer degradation and elimination from the body, biocompatibility with the brain parenchyma, and the occurrence of toxicities. Extensive studies in animal models and in patients have also provided ample evidence for the biocompatibility and biodegradability of the polymeric matrix in the area surrounding the implantation site. In this chapter, we review the innate physical barriers of the central nervous system that necessitated local delivery of therapeutics, and review the modeling that helps predict compound distribution and dissolution within the intracranial space.

Original languageEnglish (US)
Title of host publicationNervous System Drug Delivery
Subtitle of host publicationPrinciples and Practice
PublisherElsevier
Pages91-109
Number of pages19
ISBN (Electronic)9780128139981
ISBN (Print)9780128139974
DOIs
StatePublished - Jun 25 2019

Keywords

  • Blood-brain barrier
  • Blood-brain tumor barrier
  • Polymeric delivery

ASJC Scopus subject areas

  • General Medicine

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