Pharmacokinetics of anidulafungin in pleural fluid during the treatment of a patient with Candida empyema

Brad Moriyama; Marisa Ditullio; Eleanor Wilson; Stacey A. Henning; Scott R. Penzak; Robert L. Danner; Gennethel Pennick; Michael G. Rinaldi; Adrian M. Zelazny; Juan Gea-Banacloche; A. John Barrett; Thomas J. Walsh

doi:10.1128/AAC.01560-10

Pharmacokinetics of anidulafungin in pleural fluid during the treatment of a patient with Candida empyema

Brad Moriyama, Marisa Ditullio, Eleanor Wilson, Stacey A. Henning, Scott R. Penzak, Robert L. Danner, Gennethel Pennick, Michael G. Rinaldi, Adrian M. Zelazny, Juan Gea-Banacloche, A. John Barrett, Thomas J. Walsh

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12 Scopus citations

Abstract

Candida empyema is a serious complication of disseminated candidiasis. However, little is known about the intrapleural pharmacokinetics of echinocandins. We report the penetration of anidulafungin into the pleural fluid of a patient with Candida tropicalis empyema. The anidulafungin ratio for the area under the concentration-time curve from 0 h to the last measurement between pleural fluid and serum values was only 0.125 (12.5%), with pleural fluid concentrations ranging between 0.67 and 0.88 μg/ml.

Original language	English (US)
Pages (from-to)	2478-2480
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	55
Issue number	5
DOIs	https://doi.org/10.1128/AAC.01560-10
State	Published - May 2011
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Moriyama, B., Ditullio, M., Wilson, E., Henning, S. A., Penzak, S. R., Danner, R. L., Pennick, G., Rinaldi, M. G., Zelazny, A. M., Gea-Banacloche, J., Barrett, A. J., & Walsh, T. J. (2011). Pharmacokinetics of anidulafungin in pleural fluid during the treatment of a patient with Candida empyema. Antimicrobial agents and chemotherapy, 55(5), 2478-2480. https://doi.org/10.1128/AAC.01560-10

Moriyama, B, Ditullio, M, Wilson, E, Henning, SA, Penzak, SR, Danner, RL, Pennick, G, Rinaldi, MG, Zelazny, AM, Gea-Banacloche, J, Barrett, AJ & Walsh, TJ 2011, 'Pharmacokinetics of anidulafungin in pleural fluid during the treatment of a patient with Candida empyema', Antimicrobial agents and chemotherapy, vol. 55, no. 5, pp. 2478-2480. https://doi.org/10.1128/AAC.01560-10

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title = "Pharmacokinetics of anidulafungin in pleural fluid during the treatment of a patient with Candida empyema",

abstract = "Candida empyema is a serious complication of disseminated candidiasis. However, little is known about the intrapleural pharmacokinetics of echinocandins. We report the penetration of anidulafungin into the pleural fluid of a patient with Candida tropicalis empyema. The anidulafungin ratio for the area under the concentration-time curve from 0 h to the last measurement between pleural fluid and serum values was only 0.125 (12.5%), with pleural fluid concentrations ranging between 0.67 and 0.88 μg/ml.",

author = "Brad Moriyama and Marisa Ditullio and Eleanor Wilson and Henning, {Stacey A.} and Penzak, {Scott R.} and Danner, {Robert L.} and Gennethel Pennick and Rinaldi, {Michael G.} and Zelazny, {Adrian M.} and Juan Gea-Banacloche and Barrett, {A. John} and Walsh, {Thomas J.}",

year = "2011",

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doi = "10.1128/AAC.01560-10",

language = "English (US)",

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T1 - Pharmacokinetics of anidulafungin in pleural fluid during the treatment of a patient with Candida empyema

AU - Moriyama, Brad

AU - Ditullio, Marisa

AU - Wilson, Eleanor

AU - Henning, Stacey A.

AU - Penzak, Scott R.

AU - Danner, Robert L.

AU - Pennick, Gennethel

AU - Rinaldi, Michael G.

AU - Zelazny, Adrian M.

AU - Gea-Banacloche, Juan

AU - Barrett, A. John

AU - Walsh, Thomas J.

PY - 2011/5

Y1 - 2011/5

N2 - Candida empyema is a serious complication of disseminated candidiasis. However, little is known about the intrapleural pharmacokinetics of echinocandins. We report the penetration of anidulafungin into the pleural fluid of a patient with Candida tropicalis empyema. The anidulafungin ratio for the area under the concentration-time curve from 0 h to the last measurement between pleural fluid and serum values was only 0.125 (12.5%), with pleural fluid concentrations ranging between 0.67 and 0.88 μg/ml.

AB - Candida empyema is a serious complication of disseminated candidiasis. However, little is known about the intrapleural pharmacokinetics of echinocandins. We report the penetration of anidulafungin into the pleural fluid of a patient with Candida tropicalis empyema. The anidulafungin ratio for the area under the concentration-time curve from 0 h to the last measurement between pleural fluid and serum values was only 0.125 (12.5%), with pleural fluid concentrations ranging between 0.67 and 0.88 μg/ml.

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Pharmacokinetics of anidulafungin in pleural fluid during the treatment of a patient with Candida empyema

Abstract

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