@article{2daaedd5b369427b99b35d1ba7c83db7,
title = "Pharmacokinetic studies of prednisolone in children. Plasma levels, half-life values, and correlation with physiologic assays for growth and immunity",
abstract = "Plasma prednisolone levels have been measured hourly in children receiving a single dose of oral prednisone. Peak prednisolone levels occurred one to two hours after ingestion; half-life studies gave a mean value of 132 minutes in most children. Some children had marked variability in absorption and metabolism of prednisone. Somatomedin activity and cell-mediated immunity were inhibited by plasma prednisolone values which were achieved by single doses of prednisone of 0.5 mg/kg or higher. Monitoring prednisolone levels may be value in identifying those children who accumulate excessively high levels on moderate dosage regimens.",
author = "Green, {Orville C.} and Winter, {Robert J.} and Kawahara, {Frank S.} and Phillips, {Lawrence S.} and Lewy, {Peter R.} and Hart, {Robert L.} and Pachman, {Lauren M.} and Lietman, {Paul S.}",
note = "Funding Information: From the Departments of Pediatrics and Medicine and The Center for Endocrinolog); Northwestern University Medical School, and The Children's Memorial Hospital Supported in part by National Institutes of Health Grants RR-OI99, AM-10699, AM-21483, AM-07169, a Research and Development Award from the American Diabetes Association, Tile Greater Chicago and Northern lllinois Affiliate of the American Diabetes Association, and The Aaron Fox Foundation. Portions of this paper were presented at the Annual Meeting of the Society for Pediatric Research/ American Pediatric Society, San Francisco, CA, April 1977. *Reprint address: The Children's Memorial ttospital, 2300 Children's Plaza, Chicago, IL 60614.",
year = "1978",
month = aug,
doi = "10.1016/S0022-3476(78)80529-0",
language = "English (US)",
volume = "93",
pages = "299--303",
journal = "The Journal of pediatrics",
issn = "0022-3476",
publisher = "Elsevier Inc.",
number = "2",
}