Pharmacokinetic evidence for an enterohepatic circulation in a patient treated with cis-dichlorodiammineplatinum (II)

J. B. Vermorken, W. J F Van der Vijgh, H. M. Pinedo

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Platinum concentrations in plasma were measured by atomic absorption spectrometry during and after a 15 min intravenous infusion of cis-dichlorodiammineplatinum (II) (cis-platinum) at a dose of 100 mg/m2. Plasma concentrations of platinum declined biexponentially (t( 1/2 α)=21.3 min, t( 1/2 β)=6.2 days). A small peak was noticed at 3.5 hrs after the end of the infusion, indicating a renewed influx of platinum in the plasma compartment. This phenomenon is strongly suggestive for the presence of an enterohepatic circulation.

Original languageEnglish (US)
Pages (from-to)319-328
Number of pages10
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume28
Issue number2
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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