TY - JOUR
T1 - Phage therapy in prostatitis
T2 - Recent prospects
AU - Górski, Andrzej
AU - Jonczyk-Matysiak, Ewa
AU - Lusiak-Szelachowska, Marzanna
AU - Miedzybrodzki, Ryszard
AU - Weber-Dabrowska, Beata
AU - Borysowski, Jan
AU - Letkiewicz, Slawomir
AU - Baginska, Natalia
AU - Sfanos, Karen S.
N1 - Publisher Copyright:
© 2018 Górski, Jonczyk-Matysiak, Lusiak-Szelachowska, Miedzybrodzki, Weber-Dabrowska, Borysowski, Letkiewicz, Baginska and Sfanos.
PY - 2018/6/29
Y1 - 2018/6/29
N2 - Prostatitis has various etiology including bacterial infection and dysregulated immunity; some of its forms remain a serious therapeutic challenge. Inflammation occurs in all forms of this disorder and is proposed to predispose to the development of prostate cancer (PC). There are reports that phage therapy is effective in chronic bacterial prostatitis. Recent findings suggest that phages not only eliminate bacteria, but also mediate immunomodulating (for example, anti-inflammatory) functions. The immunomodulating effects of phages could be beneficial in treating all forms of prostatitis and play some role in the prevention of the development of PC. As the etiological factors contributing to the majority of prostatitis cases remains largely unknown, and management options are often likewise limited, phage therapy merits further research as an attractive therapeutic option given its immunomodulating effects irrespective of the underlying causative factor(s).
AB - Prostatitis has various etiology including bacterial infection and dysregulated immunity; some of its forms remain a serious therapeutic challenge. Inflammation occurs in all forms of this disorder and is proposed to predispose to the development of prostate cancer (PC). There are reports that phage therapy is effective in chronic bacterial prostatitis. Recent findings suggest that phages not only eliminate bacteria, but also mediate immunomodulating (for example, anti-inflammatory) functions. The immunomodulating effects of phages could be beneficial in treating all forms of prostatitis and play some role in the prevention of the development of PC. As the etiological factors contributing to the majority of prostatitis cases remains largely unknown, and management options are often likewise limited, phage therapy merits further research as an attractive therapeutic option given its immunomodulating effects irrespective of the underlying causative factor(s).
KW - Inflammation
KW - Phage therapy
KW - Phages
KW - Prostate cancer
KW - Prostatitis
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UR - http://www.scopus.com/inward/citedby.url?scp=85049247446&partnerID=8YFLogxK
U2 - 10.3389/fmicb.2018.01434
DO - 10.3389/fmicb.2018.01434
M3 - Short survey
C2 - 30008710
AN - SCOPUS:85049247446
SN - 1664-302X
VL - 9
JO - Frontiers in Microbiology
JF - Frontiers in Microbiology
IS - JUN
M1 - 1434
ER -