Phage therapy in prostatitis: Recent prospects

Andrzej Górski, Ewa Jonczyk-Matysiak, Marzanna Lusiak-Szelachowska, Ryszard Miedzybrodzki, Beata Weber-Dabrowska, Jan Borysowski, Slawomir Letkiewicz, Natalia Baginska, Karen S. Sfanos

Research output: Contribution to journalShort surveypeer-review

7 Scopus citations


Prostatitis has various etiology including bacterial infection and dysregulated immunity; some of its forms remain a serious therapeutic challenge. Inflammation occurs in all forms of this disorder and is proposed to predispose to the development of prostate cancer (PC). There are reports that phage therapy is effective in chronic bacterial prostatitis. Recent findings suggest that phages not only eliminate bacteria, but also mediate immunomodulating (for example, anti-inflammatory) functions. The immunomodulating effects of phages could be beneficial in treating all forms of prostatitis and play some role in the prevention of the development of PC. As the etiological factors contributing to the majority of prostatitis cases remains largely unknown, and management options are often likewise limited, phage therapy merits further research as an attractive therapeutic option given its immunomodulating effects irrespective of the underlying causative factor(s).

Original languageEnglish (US)
Article number1434
JournalFrontiers in Microbiology
Issue numberJUN
StatePublished - Jun 29 2018


  • Inflammation
  • Phage therapy
  • Phages
  • Prostate cancer
  • Prostatitis

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)


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