PGC-1, a versatile coactivator

Darko Knutti, Anastasia Kralli

Research output: Contribution to journalReview articlepeer-review

235 Scopus citations


PGC-1 was originally identified as a transcriptional coactivator of the nuclear receptor PPARγ. The expression pattern and induction by exposure to cold have implicated PGC-1 in the regulation of energy metabolism and adaptive thermogenesis. Remarkably, PGC-1 overexpression can induce mitochondrial biogenesis and functions. Recent studies show that PGC-1 regulates the activity of several nuclear receptors and other transcription factors, and thus acts in a broader context than previously anticipated. Furthermore, PGC-1 displays the striking ability to interact with components of the splicing machinery. PGC-1 could therefore allow coordinated regulation of transcription and splicing in response to signals relaying metabolic needs. These novel findings are discussed in the context of the proposed physiological functions of PGC-1.

Original languageEnglish (US)
Pages (from-to)360-365
Number of pages6
JournalTrends in Endocrinology and Metabolism
Issue number8
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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