Abstract
Fluoride is a direct activator of G-proteins. In isolated rings of canine coronary artery, fluoride caused relaxation of rings with endothelium, but only slight contraction of rings denuded of endothelium. The endothelium-dependent relaxations to fluoride were inhibited by pertussis toxin, an inhibitor of G-proteins, or by methylene blue, an inhibitor of soluble guanylate cyclase. Therefore, fluoride causes endothelium-dependent relaxations in part by activating a pertussis toxin-sensitive G-protein in the endothelial cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 121-124 |
| Number of pages | 4 |
| Journal | European Journal of Pharmacology |
| Volume | 178 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 13 1990 |
| Externally published | Yes |
Keywords
- Bacterial toxins
- EDRF
- Endothelium-derived relaxing factor
- G-proteins
- guanine nucleotide regulatory proteins
ASJC Scopus subject areas
- Pharmacology
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