Perspectives in melanoma: Meeting report from the "melanoma Bridge" (December 5th-7th, 2019, Naples, Italy)

Paolo A. Ascierto, Igor Puzanov, Sanjiv S. Agarwala, Christian Blank, Richard D. Carvajal, Sandra Demaria, Reinhard Dummer, Marc Ernstoff, Soldano Ferrone, Bernard A. Fox, Thomas F. Gajewski, Claus Garbe, Patrick Hwu, Roger S. Lo, Georgina V. Long, Jason J. Luke, Iman Osman, Michael A. Postow, Ryan J. Sullivan, Janis M. TaubeGiorgio Trinchieri, Hassane M. Zarour, Corrado Caracò, Magdalena Thurin

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The melanoma treatment landscape changed in 2011 with the approval of the first anti-cytotoxic T-lymphocyte-associated protein (CTLA)-4 checkpoint inhibitor and of the first BRAF-targeted monoclonal antibody, both of which significantly improved overall survival (OS). Since then, improved understanding of the tumor microenvironment (TME) and tumor immune-evasion mechanisms has resulted in new approaches to targeting and harnessing the host immune response. The approval of new immune and targeted therapies has further improved outcomes for patients with advanced melanoma and other combination modalities are also being explored such as chemotherapy, radiotherapy, electrochemotherapy and surgery. In addition, different strategies of drugs administration including sequential or combination treatment are being tested. Approaches to overcome resistance and to potentiate the immune response are being developed. Increasing evidence emerges that tissue and blood-based biomarkers can predict the response to a therapy. The latest findings in melanoma research, including insights into the tumor microenvironment and new biomarkers, improved understanding of tumor immune response and resistance, novel approaches for combination strategies and the role of neoadjuvant and adjuvant therapy, were the focus of discussions at the Melanoma Bridge meeting (5-7 December, 2019, Naples, Italy), which are summarized in this report.

Original languageEnglish (US)
Article number346
JournalJournal of translational medicine
Issue number1
StatePublished - Sep 7 2020


  • Adjuvant
  • Anti-CTLA-4
  • Anti-PD-1
  • BRAF inhibitor
  • Biomarkers
  • CAR-T
  • Combination strategies
  • Immunotherapy
  • MEK inhibitor
  • Melanoma
  • Neoadjuvant
  • Target therapy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'Perspectives in melanoma: Meeting report from the "melanoma Bridge" (December 5th-7th, 2019, Naples, Italy)'. Together they form a unique fingerprint.

Cite this