Perspective: Virus infections and the death of neurons

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations


Neuronotropic viruses induce apoptosis in neurons, and Bcl-2-related anti-apoptotic proteins and caspase inhibitors decrease mortality from acute vital encephalitis. Infected neurons develop cytoplasmic blebbing characteristic of apoptosis, but a paucity of apoptotic nuclear changes potentially indicates unique aspects of virus-induced neuronal apoptosis that remain to be discovered.

Original languageEnglish (US)
Pages (from-to)155-160
Number of pages6
JournalTrends in Microbiology
Issue number4
StatePublished - Apr 1 1999

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology


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