Perspective: Virus infections and the death of neurons

Diane E. Griffin; J. Marie Hardwick

doi:10.1016/S0966-842X(99)01470-5

Perspective: Virus infections and the death of neurons

Diane E. Griffin, J. Marie Hardwick

Bloomberg School of Public Health

Research output: Contribution to journal › Review article › peer-review

49 Scopus citations

Abstract

Neuronotropic viruses induce apoptosis in neurons, and Bcl-2-related anti-apoptotic proteins and caspase inhibitors decrease mortality from acute vital encephalitis. Infected neurons develop cytoplasmic blebbing characteristic of apoptosis, but a paucity of apoptotic nuclear changes potentially indicates unique aspects of virus-induced neuronal apoptosis that remain to be discovered.

Original language	English (US)
Pages (from-to)	155-160
Number of pages	6
Journal	Trends in Microbiology
Volume	7
Issue number	4
DOIs	https://doi.org/10.1016/S0966-842X(99)01470-5
State	Published - Apr 1 1999

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Infectious Diseases
Virology

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10.1016/S0966-842X(99)01470-5

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title = "Perspective: Virus infections and the death of neurons",

abstract = "Neuronotropic viruses induce apoptosis in neurons, and Bcl-2-related anti-apoptotic proteins and caspase inhibitors decrease mortality from acute vital encephalitis. Infected neurons develop cytoplasmic blebbing characteristic of apoptosis, but a paucity of apoptotic nuclear changes potentially indicates unique aspects of virus-induced neuronal apoptosis that remain to be discovered.",

author = "Griffin, {Diane E.} and Hardwick, {J. Marie}",

note = "Funding Information: Work performed in our laboratories was funded by research grants from the Muscular Dystrophy Association and the National Institutes of Health (NS18596 and NS34175).",

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AU - Hardwick, J. Marie

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N2 - Neuronotropic viruses induce apoptosis in neurons, and Bcl-2-related anti-apoptotic proteins and caspase inhibitors decrease mortality from acute vital encephalitis. Infected neurons develop cytoplasmic blebbing characteristic of apoptosis, but a paucity of apoptotic nuclear changes potentially indicates unique aspects of virus-induced neuronal apoptosis that remain to be discovered.

AB - Neuronotropic viruses induce apoptosis in neurons, and Bcl-2-related anti-apoptotic proteins and caspase inhibitors decrease mortality from acute vital encephalitis. Infected neurons develop cytoplasmic blebbing characteristic of apoptosis, but a paucity of apoptotic nuclear changes potentially indicates unique aspects of virus-induced neuronal apoptosis that remain to be discovered.

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Perspective: Virus infections and the death of neurons

Abstract

ASJC Scopus subject areas

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